Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 273938..274715 Replicon chromosome
Accession NZ_CP118165
Organism Glaesserella parasuis strain XP11

Toxin (Protein)


Gene name TacT3 Uniprot ID B8F4U7
Locus tag PUV55_RS01370 Protein ID WP_005710654.1
Coordinates 273938..274438 (-) Length 167 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID U4SPD7
Locus tag PUV55_RS01375 Protein ID WP_005710653.1
Coordinates 274428..274715 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUV55_RS01335 (PUV55_01335) 269063..269218 - 156 WP_005710668.1 YoaH family protein -
PUV55_RS01340 (PUV55_01340) 269236..269964 - 729 WP_021115014.1 tRNA pseudouridine(65) synthase TruC -
PUV55_RS01345 (PUV55_01345) 269961..270275 - 315 WP_005710664.1 YqcC family protein -
PUV55_RS01350 (PUV55_01350) 270317..271231 - 915 WP_082259327.1 N-acetylmuramic acid 6-phosphate etherase -
PUV55_RS01355 (PUV55_01355) 271243..272358 - 1116 WP_035519838.1 anhydro-N-acetylmuramic acid kinase -
PUV55_RS01360 (PUV55_01360) 272513..272848 - 336 WP_005710658.1 outer membrane protein assembly factor BamE -
PUV55_RS01365 (PUV55_01365) 272909..273910 - 1002 WP_005710656.1 nucleoid-associated protein YejK -
PUV55_RS01370 (PUV55_01370) 273938..274438 - 501 WP_005710654.1 GNAT family N-acetyltransferase Toxin
PUV55_RS01375 (PUV55_01375) 274428..274715 - 288 WP_005710653.1 DUF1778 domain-containing protein Antitoxin
PUV55_RS01380 (PUV55_01380) 274861..275250 + 390 WP_035519839.1 RidA family protein -
PUV55_RS01385 (PUV55_01385) 275254..275991 + 738 WP_274359847.1 peptidoglycan editing factor PgeF -
PUV55_RS01390 (PUV55_01390) 276166..277743 + 1578 WP_010786634.1 FAD-binding protein -
PUV55_RS01395 (PUV55_01395) 277849..278349 + 501 WP_010786633.1 CvpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(4-87)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 19184.39 Da        Isoelectric Point: 9.3198

>T272916 WP_005710654.1 NZ_CP118165:c274438-273938 [Glaesserella parasuis]
MKSKFIEEPLTKHHQREAFDCGNLEMNRFFKQYARQSHEKGTSKTYISRHLDSQQIIGFYTITLSALDQQHLPELCKKRF
GYHPIPLFTLARLAVDIRYQKQGIGGMLLVKALKRCAIVAEQVWGIGLLIEAKDEDISRWYQSYGAIPLENMPLTLILLF
DTIKGL

Download         Length: 501 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10917.47 Da        Isoelectric Point: 6.4650

>AT272916 WP_005710653.1 NZ_CP118165:c274715-274428 [Glaesserella parasuis]
MPQIANALNDRMSIRISTEDKQTLIRAVALTHTNITEFVLQRILPSAREIIQQYDNRQFSPQDLSLIMELLDNPPKANTK
LQQAAKLAKESYHEE

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836YZP3

Antitoxin

Source ID Structure
AlphaFold DB U4SPD7

References