Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 875061..875585 Replicon chromosome
Accession NZ_CP118163
Organism Staphylococcus hyicus strain SG-7

Toxin (Protein)


Gene name mazF Uniprot ID A0A0A8HRS0
Locus tag PTA87_RS04240 Protein ID WP_037567539.1
Coordinates 875232..875585 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag PTA87_RS04235 Protein ID WP_107633598.1
Coordinates 875061..875231 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTA87_RS04210 870856..871332 + 477 WP_052257801.1 PH domain-containing protein -
PTA87_RS04215 871325..872815 + 1491 WP_274316368.1 PH domain-containing protein -
PTA87_RS04220 872796..873311 + 516 WP_274316369.1 PH domain-containing protein -
PTA87_RS04225 873379..873729 + 351 WP_039644672.1 holo-ACP synthase -
PTA87_RS04230 873829..874977 + 1149 WP_274316370.1 alanine racemase -
PTA87_RS04235 875061..875231 + 171 WP_107633598.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PTA87_RS04240 875232..875585 + 354 WP_037567539.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PTA87_RS04245 875662..876648 + 987 WP_241961404.1 PP2C family protein-serine/threonine phosphatase -
PTA87_RS04250 876729..877055 + 327 WP_039644676.1 anti-sigma factor antagonist -
PTA87_RS04255 877058..877537 + 480 WP_039644678.1 anti-sigma B factor RsbW -
PTA87_RS04260 877512..878282 + 771 WP_107633600.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13103.33 Da        Isoelectric Point: 10.3729

>T272914 WP_037567539.1 NZ_CP118163:875232-875585 [Staphylococcus hyicus]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKHKYKLDKDSVILLEQIRT
VDKKRLKEKLTYLSDKKMKEVNAALGISLGLHMNQHK

Download         Length: 354 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6293.94 Da        Isoelectric Point: 4.0644

>AT272914 WP_107633598.1 NZ_CP118163:875061-875231 [Staphylococcus hyicus]
MSSFYQTRGKSLEQLLKEGYVQMADLNLSLATEAYSVECEACDCNESHLLSNNKDD

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8HRS0

Antitoxin

Source ID Structure

References