Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 861545..862078 Replicon chromosome
Accession NZ_CP118163
Organism Staphylococcus hyicus strain SG-7

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0A8HPH3
Locus tag PTA87_RS04170 Protein ID WP_039644659.1
Coordinates 861845..862078 (+) Length 78 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0A8HRR0
Locus tag PTA87_RS04165 Protein ID WP_039644657.1
Coordinates 861545..861832 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTA87_RS04140 856838..857635 + 798 WP_274316363.1 hydroxyethylthiazole kinase -
PTA87_RS04145 857632..858270 + 639 WP_274316364.1 thiamine phosphate synthase -
PTA87_RS04150 858359..859225 + 867 WP_039644652.1 membrane protein insertase YidC -
PTA87_RS04155 859273..859905 - 633 WP_119635710.1 HD domain-containing protein -
PTA87_RS04160 859917..861407 - 1491 WP_039644655.1 cardiolipin synthase -
PTA87_RS04165 861545..861832 + 288 WP_039644657.1 copper-sensing transcriptional repressor CsoR Antitoxin
PTA87_RS04170 861845..862078 + 234 WP_039644659.1 hypothetical protein Toxin
PTA87_RS04175 862071..862274 + 204 WP_039644660.1 cation transporter -
PTA87_RS04180 862403..864583 + 2181 WP_274316365.1 heavy metal translocating P-type ATPase -
PTA87_RS04185 864668..864808 + 141 WP_086375151.1 Lmo0850 family protein -
PTA87_RS04190 864966..866165 - 1200 WP_039644664.1 FtsW/RodA/SpoVE family cell cycle protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(12-90)


Sequences

Toxin        


Download         Length: 78 a.a.        Molecular weight: 8851.10 Da        Isoelectric Point: 4.7769

>T272913 WP_039644659.1 NZ_CP118163:861845-862078 [Staphylococcus hyicus]
MQIDRVFVEGLDEEQQRTDLTQRLNHMIGVKGVSIDGHLQCVTLKYETPMNLNTLEKEIYDAGFKVLRTVKGEITNE

Download         Length: 234 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10999.56 Da        Isoelectric Point: 6.3268

>AT272913 WP_039644657.1 NZ_CP118163:861545-861832 [Staphylococcus hyicus]
MNDHAHHSEEIKKNLTSRLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLDYHMKGCITKKIEDGHETE
AMEELLVTFQKLMKD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8HPH3

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8HRR0

References