Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 6219832..6220421 Replicon chromosome
Accession NZ_CP118156
Organism Pseudomonas chlororaphis strain ATCC 15926

Toxin (Protein)


Gene name PumA Uniprot ID A0A285IHJ3
Locus tag PUP74_RS28125 Protein ID WP_062824477.1
Coordinates 6220122..6220421 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag PUP74_RS28120 Protein ID WP_007924096.1
Coordinates 6219832..6220125 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP74_RS28095 (PUP74_28095) 6215534..6215992 + 459 WP_009045805.1 GNAT family N-acetyltransferase -
PUP74_RS28100 (PUP74_28100) 6216246..6216902 + 657 WP_007924093.1 DedA family protein -
PUP74_RS28105 (PUP74_28105) 6216908..6217717 + 810 WP_062824480.1 zinc-dependent peptidase -
PUP74_RS28110 (PUP74_28110) 6217982..6218509 + 528 WP_009045807.1 inorganic diphosphatase -
PUP74_RS28115 (PUP74_28115) 6219324..6219716 + 393 WP_274302033.1 hypothetical protein -
PUP74_RS28120 (PUP74_28120) 6219832..6220125 - 294 WP_007924096.1 putative addiction module antidote protein Antitoxin
PUP74_RS28125 (PUP74_28125) 6220122..6220421 - 300 WP_062824477.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PUP74_RS28130 (PUP74_28130) 6220593..6221042 + 450 WP_009045812.1 DUF3828 domain-containing protein -
PUP74_RS28135 (PUP74_28135) 6221067..6222077 - 1011 WP_274302154.1 NAD(P)-dependent alcohol dehydrogenase -
PUP74_RS28140 (PUP74_28140) 6222135..6222434 - 300 WP_007924100.1 helix-turn-helix transcriptional regulator -
PUP74_RS28145 (PUP74_28145) 6222502..6223590 - 1089 WP_253366025.1 copper-containing nitrite reductase -
PUP74_RS28150 (PUP74_28150) 6223816..6224058 + 243 WP_007924102.1 exodeoxyribonuclease VII small subunit -
PUP74_RS28155 (PUP74_28155) 6224055..6224942 + 888 WP_053262814.1 (2E,6E)-farnesyl diphosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-94)

Antitoxin

Uncharacterized protein HI1420

(6-91)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11261.01 Da        Isoelectric Point: 10.8652

>T272912 WP_062824477.1 NZ_CP118156:c6220421-6220122 [Pseudomonas chlororaphis]
MIEIKQTATFMEWENRLKDSRARALIAARIFRLANGLAGDVSPVGEGVSELRIHYGPGYRVYFQQRGLQLVILLCGGDKS
RQGRDIELAKQLARRWSRS

Download         Length: 300 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10430.94 Da        Isoelectric Point: 5.6558

>AT272912 WP_007924096.1 NZ_CP118156:c6220125-6219832 [Pseudomonas chlororaphis]
MNEPLFDYDPATALRDPQAIALFMADAFETGDAGYIAKALGVVARAKGMTELAHETGLSREQLYRSFSDKGNPTLKTLLA
VMRALGLDMTARVHGAS

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285IHJ3

Antitoxin

Source ID Structure

References