Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1779491..1780113 Replicon chromosome
Accession NZ_CP118156
Organism Pseudomonas chlororaphis strain ATCC 15926

Toxin (Protein)


Gene name hicA Uniprot ID A0A285HEJ8
Locus tag PUP74_RS08055 Protein ID WP_053259927.1
Coordinates 1779931..1780113 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A285HET1
Locus tag PUP74_RS08050 Protein ID WP_009042564.1
Coordinates 1779491..1779898 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP74_RS08025 (PUP74_08025) 1774491..1775153 - 663 WP_274301359.1 NAD(P)-binding domain-containing protein -
PUP74_RS08030 (PUP74_08030) 1775256..1776146 + 891 WP_274302138.1 LysR family transcriptional regulator -
PUP74_RS08035 (PUP74_08035) 1776385..1778163 + 1779 WP_274301358.1 GGDEF and EAL domain-containing protein -
PUP74_RS08040 (PUP74_08040) 1778197..1779111 - 915 WP_274301357.1 SGNH/GDSL hydrolase family protein -
PUP74_RS08045 (PUP74_08045) 1779241..1779444 - 204 WP_239691046.1 hypothetical protein -
PUP74_RS08050 (PUP74_08050) 1779491..1779898 - 408 WP_009042564.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP74_RS08055 (PUP74_08055) 1779931..1780113 - 183 WP_053259927.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP74_RS08060 (PUP74_08060) 1781178..1781900 + 723 WP_253362990.1 molecular chaperone -
PUP74_RS08065 (PUP74_08065) 1782022..1782993 + 972 WP_274301356.1 fimbrial protein -
PUP74_RS08070 (PUP74_08070) 1783162..1783687 - 526 Protein_1591 integrase -
PUP74_RS08080 (PUP74_08080) 1784200..1785084 - 885 WP_009042569.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6873.18 Da        Isoelectric Point: 11.1084

>T272908 WP_053259927.1 NZ_CP118156:c1780113-1779931 [Pseudomonas chlororaphis]
VDSRYLIGQIVADGWYLVRVRGSHHHFKHPHKPGLVTVPHPKKDLLRKTAISILKQALLM

Download         Length: 183 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14698.72 Da        Isoelectric Point: 4.5911

>AT272908 WP_009042564.1 NZ_CP118156:c1779898-1779491 [Pseudomonas chlororaphis]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGAPIPHANKVTLHAANPRYAGCTWAL
IDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285HEJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A285HET1

References