Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 533971..534584 Replicon chromosome
Accession NZ_CP118156
Organism Pseudomonas chlororaphis strain ATCC 15926

Toxin (Protein)


Gene name hicA Uniprot ID A0A285EYZ4
Locus tag PUP74_RS02390 Protein ID WP_009041685.1
Coordinates 533971..534153 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2N8BII0
Locus tag PUP74_RS02395 Protein ID WP_009041686.1
Coordinates 534183..534584 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP74_RS02360 (PUP74_02360) 529736..529993 - 258 WP_253362330.1 hypothetical protein -
PUP74_RS02365 (PUP74_02365) 530046..530534 - 489 WP_009041680.1 DoxX family protein -
PUP74_RS02370 (PUP74_02370) 530608..531504 - 897 WP_253362331.1 SDR family oxidoreductase -
PUP74_RS02375 (PUP74_02375) 531534..532043 - 510 WP_062824006.1 DUF1097 domain-containing protein -
PUP74_RS02380 (PUP74_02380) 532077..532817 - 741 WP_009041683.1 SDR family oxidoreductase -
PUP74_RS02385 (PUP74_02385) 532956..533846 + 891 WP_053259258.1 LysR family transcriptional regulator -
PUP74_RS02390 (PUP74_02390) 533971..534153 + 183 WP_009041685.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP74_RS02395 (PUP74_02395) 534183..534584 + 402 WP_009041686.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP74_RS02400 (PUP74_02400) 534673..535719 - 1047 WP_085533366.1 LacI family DNA-binding transcriptional regulator -
PUP74_RS02405 (PUP74_02405) 535927..538185 + 2259 WP_274301721.1 TonB-dependent receptor -
PUP74_RS02410 (PUP74_02410) 538232..539557 + 1326 WP_009041689.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6933.08 Da        Isoelectric Point: 10.4588

>T272904 WP_009041685.1 NZ_CP118156:533971-534153 [Pseudomonas chlororaphis]
MRSRELIRMIEEDGWYLIAVKGSHHQYKHLHKPGRVTIPHPDADLPRGTIHSILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14629.48 Da        Isoelectric Point: 4.7569

>AT272904 WP_009041686.1 NZ_CP118156:534183-534584 [Pseudomonas chlororaphis]
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAEAFENVKEALSLHYEGLVADGEPLPQVHEVDVHIDNPDYAGGVWGMI
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285EYZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A2N8BII0

References