Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2612310..2612929 Replicon chromosome
Accession NZ_CP118155
Organism Pseudomonas chlororaphis strain ATCC 17411

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G7DMG3
Locus tag PUP78_RS11875 Protein ID WP_009048155.1
Coordinates 2612747..2612929 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A285IZU0
Locus tag PUP78_RS11870 Protein ID WP_007923747.1
Coordinates 2612310..2612711 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP78_RS11855 (PUP78_11855) 2608380..2610269 + 1890 WP_124304744.1 PAS domain S-box protein -
PUP78_RS11860 (PUP78_11860) 2610266..2610901 + 636 WP_124304745.1 response regulator transcription factor -
PUP78_RS11865 (PUP78_11865) 2610995..2611744 + 750 WP_124304746.1 hypothetical protein -
PUP78_RS11870 (PUP78_11870) 2612310..2612711 - 402 WP_007923747.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP78_RS11875 (PUP78_11875) 2612747..2612929 - 183 WP_009048155.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP78_RS11880 (PUP78_11880) 2613221..2613502 - 282 WP_124304747.1 hypothetical protein -
PUP78_RS11885 (PUP78_11885) 2614146..2616305 - 2160 WP_164486009.1 AAA family ATPase -
PUP78_RS11890 (PUP78_11890) 2616646..2617194 - 549 WP_124304749.1 YniB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6799.98 Da        Isoelectric Point: 10.9678

>T272900 WP_009048155.1 NZ_CP118155:c2612929-2612747 [Pseudomonas chlororaphis]
VQSRQLIKELEAAGWVLERVTGSHHLFKHPYRPETVPVPHPKKDLPRGTVRAIQKLAGLI

Download         Length: 183 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14579.54 Da        Isoelectric Point: 4.6017

>AT272900 WP_007923747.1 NZ_CP118155:c2612711-2612310 [Pseudomonas chlororaphis]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAIEIAHVMLEELAREGQAIPLPSPTGTHRANPDFEGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQRIDRFVREHNIKSRSSFLADAAMEKLGR

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G7DMG3

Antitoxin

Source ID Structure
AlphaFold DB A0A285IZU0

References