Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1782577..1783199 Replicon chromosome
Accession NZ_CP118155
Organism Pseudomonas chlororaphis strain ATCC 17411

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PUP78_RS08125 Protein ID WP_106696706.1
Coordinates 1783017..1783199 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PUP78_RS08120 Protein ID WP_106698998.1
Coordinates 1782577..1782984 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP78_RS08100 (PUP78_08100) 1777879..1778772 + 894 WP_173678573.1 LysR family transcriptional regulator -
PUP78_RS08105 (PUP78_08105) 1779008..1780786 + 1779 WP_124323664.1 GGDEF and EAL domain-containing protein -
PUP78_RS08110 (PUP78_08110) 1780820..1781734 - 915 WP_124323665.1 SGNH/GDSL hydrolase family protein -
PUP78_RS08115 (PUP78_08115) 1781864..1782331 - 468 WP_106696705.1 GAF domain-containing protein -
PUP78_RS08120 (PUP78_08120) 1782577..1782984 - 408 WP_106698998.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP78_RS08125 (PUP78_08125) 1783017..1783199 - 183 WP_106696706.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP78_RS08135 (PUP78_08135) 1783918..1784802 - 885 WP_009047472.1 alpha/beta hydrolase -
PUP78_RS08140 (PUP78_08140) 1785154..1785846 - 693 WP_025804997.1 16S rRNA pseudouridine(516) synthase -
PUP78_RS08145 (PUP78_08145) 1785880..1786098 - 219 WP_274346761.1 cysteine-rich CWC family protein -
PUP78_RS08150 (PUP78_08150) 1786106..1787593 - 1488 WP_106696708.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6810.12 Da        Isoelectric Point: 11.6709

>T272899 WP_106696706.1 NZ_CP118155:c1783199-1783017 [Pseudomonas chlororaphis]
VNSRYLIGQIVADGWYLVRVRGSHHPFRHPSKPGLVTVPHPKKDLLRKTAISILKQALLM

Download         Length: 183 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14657.65 Da        Isoelectric Point: 4.4710

>AT272899 WP_106698998.1 NZ_CP118155:c1782984-1782577 [Pseudomonas chlororaphis]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGAAIPPANKVTLHAANPQYAGRTWAL
IDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References