Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3646880..3647493 Replicon chromosome
Accession NZ_CP118154
Organism Pseudomonas chlororaphis strain ATCC 17414

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PUP71_RS16620 Protein ID WP_053259259.1
Coordinates 3647311..3647493 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2N8BII0
Locus tag PUP71_RS16615 Protein ID WP_009041686.1
Coordinates 3646880..3647281 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP71_RS16600 (PUP71_16600) 3641908..3643233 - 1326 WP_009041689.1 LLM class flavin-dependent oxidoreductase -
PUP71_RS16605 (PUP71_16605) 3643280..3645538 - 2259 WP_053259261.1 TonB-dependent receptor -
PUP71_RS16610 (PUP71_16610) 3645745..3646791 + 1047 WP_053259260.1 LacI family DNA-binding transcriptional regulator -
PUP71_RS16615 (PUP71_16615) 3646880..3647281 - 402 WP_009041686.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP71_RS16620 (PUP71_16620) 3647311..3647493 - 183 WP_053259259.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP71_RS16625 (PUP71_16625) 3647618..3648508 - 891 WP_053259258.1 LysR family transcriptional regulator -
PUP71_RS16630 (PUP71_16630) 3648647..3649387 + 741 WP_053259257.1 SDR family oxidoreductase -
PUP71_RS16635 (PUP71_16635) 3649421..3649930 + 510 WP_053259256.1 DUF1097 domain-containing protein -
PUP71_RS16640 (PUP71_16640) 3649960..3650856 + 897 WP_007925288.1 SDR family oxidoreductase -
PUP71_RS16645 (PUP71_16645) 3651096..3651353 + 258 WP_053259255.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6959.11 Da        Isoelectric Point: 10.2817

>T272893 WP_053259259.1 NZ_CP118154:c3647493-3647311 [Pseudomonas chlororaphis]
MRSRELIRMIEEDGWYLIAVKGSHHQYKYLHKPGRVTIPHPDADLPRGTIHSILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14629.48 Da        Isoelectric Point: 4.7569

>AT272893 WP_009041686.1 NZ_CP118154:c3647281-3646880 [Pseudomonas chlororaphis]
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAEAFENVKEALSLHYEGLVADGEPLPQVHEVDVHIDNPDYAGGVWGMI
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2N8BII0

References