Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2421471..2422093 Replicon chromosome
Accession NZ_CP118154
Organism Pseudomonas chlororaphis strain ATCC 17414

Toxin (Protein)


Gene name hicA Uniprot ID A0A285HEJ8
Locus tag PUP71_RS11065 Protein ID WP_053259927.1
Coordinates 2421471..2421653 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A285HET1
Locus tag PUP71_RS11070 Protein ID WP_009042564.1
Coordinates 2421686..2422093 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP71_RS11045 (PUP71_11045) 2417079..2417822 + 744 WP_053259931.1 hypothetical protein -
PUP71_RS11050 (PUP71_11050) 2417937..2418497 - 561 Protein_2188 HipA domain-containing protein -
PUP71_RS11055 (PUP71_11055) 2418621..2419580 - 960 WP_053259929.1 fimbrial protein -
PUP71_RS11060 (PUP71_11060) 2419691..2420407 - 717 WP_053259928.1 molecular chaperone -
PUP71_RS11065 (PUP71_11065) 2421471..2421653 + 183 WP_053259927.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP71_RS11070 (PUP71_11070) 2421686..2422093 + 408 WP_009042564.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP71_RS11075 (PUP71_11075) 2422299..2423213 + 915 WP_053259926.1 SGNH/GDSL hydrolase family protein -
PUP71_RS11080 (PUP71_11080) 2423247..2425025 - 1779 WP_053259925.1 sensor domain-containing phosphodiesterase -
PUP71_RS11085 (PUP71_11085) 2425263..2426153 - 891 WP_053260051.1 LysR family transcriptional regulator -
PUP71_RS11090 (PUP71_11090) 2426256..2426918 + 663 WP_053259924.1 NAD(P)-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6873.18 Da        Isoelectric Point: 11.1084

>T272891 WP_053259927.1 NZ_CP118154:2421471-2421653 [Pseudomonas chlororaphis]
VDSRYLIGQIVADGWYLVRVRGSHHHFKHPHKPGLVTVPHPKKDLLRKTAISILKQALLM

Download         Length: 183 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14698.72 Da        Isoelectric Point: 4.5911

>AT272891 WP_009042564.1 NZ_CP118154:2421686-2422093 [Pseudomonas chlororaphis]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGAPIPHANKVTLHAANPRYAGCTWAL
IDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285HEJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A285HET1

References