272886

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1870436..1871058 Replicon chromosome
Accession NZ_CP118153
Organism Pseudomonas chlororaphis strain ATCC 17811

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PUP50_RS08505 Protein ID WP_087089111.1
Coordinates 1870876..1871058 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PUP50_RS08500 Protein ID WP_274305792.1
Coordinates 1870436..1870843 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP50_RS08480 (PUP50_08480) 1865742..1866632 + 891 WP_274306755.1 LysR family transcriptional regulator -
PUP50_RS08485 (PUP50_08485) 1866870..1868648 + 1779 WP_274305789.1 sensor domain-containing phosphodiesterase -
PUP50_RS08490 (PUP50_08490) 1868682..1869596 - 915 WP_274305790.1 SGNH/GDSL hydrolase family protein -
PUP50_RS08495 (PUP50_08495) 1869726..1870193 - 468 WP_274305791.1 GAF domain-containing protein -
PUP50_RS08500 (PUP50_08500) 1870436..1870843 - 408 WP_274305792.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP50_RS08505 (PUP50_08505) 1870876..1871058 - 183 WP_087089111.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP50_RS08515 (PUP50_08515) 1871780..1872664 - 885 WP_101337082.1 alpha/beta hydrolase -
PUP50_RS08520 (PUP50_08520) 1873016..1873708 - 693 WP_274305793.1 16S rRNA pseudouridine(516) synthase -
PUP50_RS08525 (PUP50_08525) 1873742..1873960 - 219 WP_274306756.1 cysteine-rich CWC family protein -
PUP50_RS08530 (PUP50_08530) 1873968..1875455 - 1488 WP_274305794.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6851.13 Da        Isoelectric Point: 11.3078

>T272886 WP_087089111.1 NZ_CP118153:c1871058-1870876 [Pseudomonas chlororaphis]
VDSRYLIGQIVADGWYLVRVRGSHHHFRHPSKPGLVTVPHPKKDLLRKTAISILKQALLM

Download         Length: 183 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14683.75 Da        Isoelectric Point: 4.7040

>AT272886 WP_274305792.1 NZ_CP118153:c1870843-1870436 [Pseudomonas chlororaphis]
MLYPIAISMGDDKHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGAPIPHANKVTLHAANPQYAGCTWAL
IDIDITKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References