Detailed information of TA system TA272880

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 717469..718088
• Replicon: chromosome
• Accession: NZ_CP118152
• Organism: Pseudomonas chlororaphis strain ATCC 336631

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: PUP64_RS03290
• Protein ID: WP_081363244.1
• Coordinates: 717469..717651 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A285IZU0
• Locus tag: PUP64_RS03295
• Protein ID: WP_007923747.1
• Coordinates: 717687..718088 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PUP64_RS03260 (PUP64_03260)	712707..712817	-	111	Protein_650	serine recombinase	-
PUP64_RS03265 (PUP64_03265)	712940..713650	+	711	WP_124344722.1	DUF5343 domain-containing protein	-
PUP64_RS03270 (PUP64_03270)	713634..714110	+	477	WP_081362137.1	TIGR02391 family protein	-
PUP64_RS03275 (PUP64_03275)	714432..715343	-	912	WP_124344721.1	hypothetical protein	-
PUP64_RS03280 (PUP64_03280)	716096..716473	+	378	WP_081362139.1	hypothetical protein	-
PUP64_RS03285 (PUP64_03285)	716896..717177	+	282	WP_081362140.1	hypothetical protein	-
PUP64_RS03290 (PUP64_03290)	717469..717651	+	183	WP_081363244.1	type II toxin-antitoxin system HicA family toxin	Toxin
PUP64_RS03295 (PUP64_03295)	717687..718088	+	402	WP_007923747.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
PUP64_RS03300 (PUP64_03300)	718834..719583	-	750	WP_081362141.1	hypothetical protein	-
PUP64_RS03305 (PUP64_03305)	719677..720312	-	636	WP_081362142.1	response regulator transcription factor	-
PUP64_RS03310 (PUP64_03310)	720309..722198	-	1890	WP_081362143.1	PAS domain S-box protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6759.96 Da
• Isoelectric Point: 10.9678

>T272880 WP_081363244.1 NZ_CP118152:717469-717651 [Pseudomonas chlororaphis]
VQSRQLIKELEAAGWVLERVTGSHHLFKPPYRPETVPVPHPKKDLPRGTVRAIQKLAGLI

Nucleotide

• Length: 183 bp

>T272880 NZ_CP118152:717469-717651 [Pseudomonas chlororaphis]
GTGCAAAGCAGACAGTTGATCAAGGAGCTTGAAGCCGCAGGCTGGGTGCTGGAGCGCGTTACCGGCAGCCATCATCTGTT
CAAGCCTCCCTACCGGCCGGAGACCGTTCCAGTGCCTCACCCGAAGAAGGATCTGCCACGGGGGACGGTCAGGGCCATCC
AGAAACTGGCCGGGCTGATATAG

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14579.54 Da
• Isoelectric Point: 4.6017

>AT272880 WP_007923747.1 NZ_CP118152:717687-718088 [Pseudomonas chlororaphis]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAIEIAHVMLEELAREGQAIPLPSPTGTHRANPDFEGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQRIDRFVREHNIKSRSSFLADAAMEKLGR

Nucleotide

• Length: 402 bp

>AT272880 NZ_CP118152:717687-718088 [Pseudomonas chlororaphis]
GTGCAATATCCCATCTGCATCGAGTGGGGCGACGAGCACACTGCTACCGGCATCCAGATTCCTGACATTCCTGGCGCGGT
CACCGCCGGCGACACCTTCGAGGCCGCGTACAGCGCCGCCATCGAGATCGCCCACGTCATGCTCGAAGAGCTGGCCCGTG
AGGGGCAAGCCATTCCCCTGCCCTCGCCCACCGGCACACACCGCGCCAACCCCGACTTCGAGGGGATGGGCTGGGGCATG
CTGGATATCGACATCACGCCTTACCTGGGCAAAACCGAAAAGGTCAATGTGACCCTGCCGGGCTACGTGATTCAACGAAT
CGACCGCTTTGTACGGGAGCACAACATCAAGAGCCGGTCGTCTTTCCTGGCGGATGCGGCGATGGAAAAGCTGGGGCGTT
AA

Structures

Antitoxin

• AlphaFold DB: A0A285IZU0