Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1215384..1216006 Replicon chromosome
Accession NZ_CP118151
Organism Pseudomonas chlororaphis strain ATCC 9446

Toxin (Protein)


Gene name hicA Uniprot ID A0A285HEJ8
Locus tag PUP54_RS05515 Protein ID WP_053259927.1
Coordinates 1215824..1216006 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A285HET1
Locus tag PUP54_RS05510 Protein ID WP_009042564.1
Coordinates 1215384..1215791 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP54_RS05490 (PUP54_05490) 1210559..1211221 - 663 WP_053259924.1 NAD(P)-binding domain-containing protein -
PUP54_RS05495 (PUP54_05495) 1211324..1212214 + 891 WP_053260051.1 LysR family transcriptional regulator -
PUP54_RS05500 (PUP54_05500) 1212452..1214230 + 1779 WP_053259925.1 sensor domain-containing phosphodiesterase -
PUP54_RS05505 (PUP54_05505) 1214264..1215178 - 915 WP_053259926.1 SGNH/GDSL hydrolase family protein -
PUP54_RS05510 (PUP54_05510) 1215384..1215791 - 408 WP_009042564.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP54_RS05515 (PUP54_05515) 1215824..1216006 - 183 WP_053259927.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP54_RS05520 (PUP54_05520) 1217070..1217786 + 717 WP_053259928.1 molecular chaperone -
PUP54_RS05525 (PUP54_05525) 1217897..1218856 + 960 WP_053259929.1 fimbrial protein -
PUP54_RS05530 (PUP54_05530) 1218980..1219540 + 561 Protein_1090 HipA domain-containing protein -
PUP54_RS05535 (PUP54_05535) 1219655..1220398 - 744 WP_053259931.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6873.18 Da        Isoelectric Point: 11.1084

>T272876 WP_053259927.1 NZ_CP118151:c1216006-1215824 [Pseudomonas chlororaphis]
VDSRYLIGQIVADGWYLVRVRGSHHHFKHPHKPGLVTVPHPKKDLLRKTAISILKQALLM

Download         Length: 183 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14698.72 Da        Isoelectric Point: 4.5911

>AT272876 WP_009042564.1 NZ_CP118151:c1215791-1215384 [Pseudomonas chlororaphis]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGAPIPHANKVTLHAANPRYAGCTWAL
IDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285HEJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A285HET1

References