Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2590584..2591203 Replicon chromosome
Accession NZ_CP118150
Organism Pseudomonas chlororaphis strain DSM 21509

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PUP49_RS11975 Protein ID WP_053278351.1
Coordinates 2591021..2591203 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PUP49_RS11970 Protein ID WP_053278311.1
Coordinates 2590584..2590985 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP49_RS11955 (PUP49_11955) 2586769..2588658 + 1890 WP_053278308.1 PAS domain S-box protein -
PUP49_RS11960 (PUP49_11960) 2588655..2589290 + 636 WP_053278309.1 response regulator transcription factor -
PUP49_RS11965 (PUP49_11965) 2589383..2590132 + 750 WP_053278310.1 hypothetical protein -
PUP49_RS11970 (PUP49_11970) 2590584..2590985 - 402 WP_053278311.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP49_RS11975 (PUP49_11975) 2591021..2591203 - 183 WP_053278351.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP49_RS11980 (PUP49_11980) 2591581..2591862 - 282 WP_053278312.1 hypothetical protein -
PUP49_RS11985 (PUP49_11985) 2592280..2592636 - 357 WP_053278313.1 hypothetical protein -
PUP49_RS11990 (PUP49_11990) 2592621..2592986 - 366 Protein_2357 hypothetical protein -
PUP49_RS11995 (PUP49_11995) 2593145..2593426 - 282 WP_053278315.1 hypothetical protein -
PUP49_RS12000 (PUP49_12000) 2594141..2595433 + 1293 WP_164487001.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2584965..2596359 11394


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6799.98 Da        Isoelectric Point: 10.9678

>T272871 WP_053278351.1 NZ_CP118150:c2591203-2591021 [Pseudomonas chlororaphis]
VQSRQLIKELEAAGWVLERVTGSHHLFKHPYRPETVPVPHPKKDLPRGTVRAIQKLAGLL

Download         Length: 183 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14591.59 Da        Isoelectric Point: 4.6017

>AT272871 WP_053278311.1 NZ_CP118150:c2590985-2590584 [Pseudomonas chlororaphis]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAIEIAHVMLEELAREGQAIPLPSPTGIHRANPDFEGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQRIDRFVREHNIKSRSSFLADAAMEKLGR

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References