Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1804876..1805498 Replicon chromosome
Accession NZ_CP118150
Organism Pseudomonas chlororaphis strain DSM 21509

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PUP49_RS08185 Protein ID WP_053277798.1
Coordinates 1805316..1805498 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PUP49_RS08180 Protein ID WP_053277797.1
Coordinates 1804876..1805283 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP49_RS08160 (PUP49_08160) 1800236..1801126 + 891 WP_053277793.1 LysR family transcriptional regulator -
PUP49_RS08165 (PUP49_08165) 1801363..1803141 + 1779 WP_053277794.1 GGDEF and EAL domain-containing protein -
PUP49_RS08170 (PUP49_08170) 1803175..1804089 - 915 WP_053277795.1 SGNH/GDSL hydrolase family protein -
PUP49_RS08175 (PUP49_08175) 1804219..1804686 - 468 WP_053277796.1 GAF domain-containing protein -
PUP49_RS08180 (PUP49_08180) 1804876..1805283 - 408 WP_053277797.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP49_RS08185 (PUP49_08185) 1805316..1805498 - 183 WP_053277798.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP49_RS08190 (PUP49_08190) 1806564..1807280 + 717 WP_053277799.1 molecular chaperone -
PUP49_RS08195 (PUP49_08195) 1807388..1808359 + 972 WP_053277800.1 fimbrial protein -
PUP49_RS08200 (PUP49_08200) 1808528..1809132 - 605 Protein_1617 Arm DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6770.10 Da        Isoelectric Point: 11.6709

>T272870 WP_053277798.1 NZ_CP118150:c1805498-1805316 [Pseudomonas chlororaphis]
VNSRYLIGQIVADGWYLVRVRGSHHPFRPPSKPGLVTVPHPKKDLLRKTAISILKQALLM

Download         Length: 183 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14594.56 Da        Isoelectric Point: 4.3638

>AT272870 WP_053277797.1 NZ_CP118150:c1805283-1804876 [Pseudomonas chlororaphis]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGAAIPSANKVTLHAANPQYAGCTWAL
IDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References