Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 6411127..6411716 Replicon chromosome
Accession NZ_CP118149
Organism Pseudomonas chlororaphis strain NCCB 60037

Toxin (Protein)


Gene name PumA Uniprot ID A0A554PHZ9
Locus tag PUP59_RS29105 Protein ID WP_041987451.1
Coordinates 6411417..6411716 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag PUP59_RS29100 Protein ID WP_041987449.1
Coordinates 6411127..6411420 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP59_RS29080 (PUP59_29080) 6406668..6407831 - 1164 WP_041987444.1 acyltransferase -
PUP59_RS29085 (PUP59_29085) 6408026..6409216 - 1191 WP_041987447.1 serine hydrolase domain-containing protein -
PUP59_RS29090 (PUP59_29090) 6409343..6410230 + 888 WP_009051074.1 LysR family transcriptional regulator -
PUP59_RS29095 (PUP59_29095) 6410602..6410994 + 393 WP_009051075.1 hypothetical protein -
PUP59_RS29100 (PUP59_29100) 6411127..6411420 - 294 WP_041987449.1 putative addiction module antidote protein Antitoxin
PUP59_RS29105 (PUP59_29105) 6411417..6411716 - 300 WP_041987451.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PUP59_RS29110 (PUP59_29110) 6411887..6412336 + 450 WP_041987453.1 DUF3828 domain-containing protein -
PUP59_RS29115 (PUP59_29115) 6412361..6413371 - 1011 WP_172833408.1 NAD(P)-dependent alcohol dehydrogenase -
PUP59_RS29120 (PUP59_29120) 6413429..6413728 - 300 WP_009051080.1 helix-turn-helix transcriptional regulator -
PUP59_RS29125 (PUP59_29125) 6413792..6414883 - 1092 WP_041987461.1 copper-containing nitrite reductase -
PUP59_RS29130 (PUP59_29130) 6415109..6415351 + 243 WP_007924102.1 exodeoxyribonuclease VII small subunit -
PUP59_RS29135 (PUP59_29135) 6415348..6416235 + 888 WP_009051083.1 (2E,6E)-farnesyl diphosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11231.97 Da        Isoelectric Point: 10.6086

>T272867 WP_041987451.1 NZ_CP118149:c6411716-6411417 [Pseudomonas chlororaphis]
MIEIKQTATFMEWENRLKDSRARALIAARIFRLANGLAGDVPPVGEGVSELRIHYGPGYRVYFQQLGSQLVILLCGGDKS
RQSRDIELAKQLARRWSRS

Download         Length: 300 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10446.94 Da        Isoelectric Point: 5.6558

>AT272867 WP_041987449.1 NZ_CP118149:c6411420-6411127 [Pseudomonas chlororaphis]
MNEPLFDYDPATSLRDPQAIALFMADAFETGDAGYIAKALGVVARAKGMTELAHETGLSREQLYRSFSDKGNPTLKTLLA
VMRALGLDMTARVHGAS

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A554PHZ9

Antitoxin

Source ID Structure

References