272858

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2508677..2509262 Replicon chromosome
Accession NZ_CP118148
Organism Pseudomonas chlororaphis strain NCCB 880622

Toxin (Protein)


Gene name PumA Uniprot ID A0A7S5HMS4
Locus tag PUP58_RS11335 Protein ID WP_016705075.1
Coordinates 2508969..2509262 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A8A9ZIA4
Locus tag PUP58_RS11330 Protein ID WP_009048177.1
Coordinates 2508677..2508967 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP58_RS11320 (PUP58_11320) 2506189..2507571 + 1383 WP_009048175.1 efflux transporter outer membrane subunit -
PUP58_RS11325 (PUP58_11325) 2507690..2508277 + 588 WP_028682910.1 hypothetical protein -
PUP58_RS11330 (PUP58_11330) 2508677..2508967 - 291 WP_009048177.1 putative addiction module antidote protein Antitoxin
PUP58_RS11335 (PUP58_11335) 2508969..2509262 - 294 WP_016705075.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PUP58_RS11340 (PUP58_11340) 2509497..2510891 - 1395 WP_124313189.1 VOC family protein -
PUP58_RS11345 (PUP58_11345) 2511156..2512280 + 1125 WP_274319337.1 diguanylate cyclase -
PUP58_RS11350 (PUP58_11350) 2512374..2513618 + 1245 WP_274319338.1 M20/M25/M40 family metallo-hydrolase -
PUP58_RS11355 (PUP58_11355) 2513857..2514255 + 399 WP_124313192.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-97)

Antitoxin

Uncharacterized protein HI1420

(9-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10699.27 Da        Isoelectric Point: 10.0959

>T272858 WP_016705075.1 NZ_CP118148:c2509262-2508969 [Pseudomonas chlororaphis]
MDYEILQTTVFAQWHTTLRDLRARIAIARRIERASAGNLGDVKNLGGGLSEMRVNTGAGYRLYFTVRGNTLIVLLLGGDK
SSQPADICQARSLAKEF

Download         Length: 294 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10279.84 Da        Isoelectric Point: 8.0096

>AT272858 WP_009048177.1 NZ_CP118148:c2508967-2508677 [Pseudomonas chlororaphis]
MSDTLVPFDIATLLDSDQAISEYLSQVLADGDTDELIRALGHVARARGMTQIAKTTGQGRASLYKAFAPGAKPRFDTVVK
VMRALGLQLCTTVPRG

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7S5HMS4

Antitoxin

Source ID Structure
AlphaFold DB A0A8A9ZIA4

References