272855

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 541577..542190 Replicon chromosome
Accession NZ_CP118148
Organism Pseudomonas chlororaphis strain NCCB 880622

Toxin (Protein)


Gene name hicA Uniprot ID A0A285EYZ4
Locus tag PUP58_RS02430 Protein ID WP_009041685.1
Coordinates 541577..541759 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A554PT90
Locus tag PUP58_RS02435 Protein ID WP_009046450.1
Coordinates 541789..542190 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP58_RS02400 (PUP58_02400) 537352..537609 - 258 WP_009046444.1 hypothetical protein -
PUP58_RS02405 (PUP58_02405) 537662..538150 - 489 WP_041985368.1 DoxX family protein -
PUP58_RS02410 (PUP58_02410) 538224..539120 - 897 WP_041985371.1 SDR family oxidoreductase -
PUP58_RS02415 (PUP58_02415) 539149..539658 - 510 WP_274319199.1 DUF1097 domain-containing protein -
PUP58_RS02420 (PUP58_02420) 539692..540432 - 741 WP_274319200.1 SDR family oxidoreductase -
PUP58_RS02425 (PUP58_02425) 540562..541452 + 891 WP_041985374.1 LysR family transcriptional regulator -
PUP58_RS02430 (PUP58_02430) 541577..541759 + 183 WP_009041685.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP58_RS02435 (PUP58_02435) 541789..542190 + 402 WP_009046450.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP58_RS02440 (PUP58_02440) 542760..543797 + 1038 WP_124314665.1 L-glyceraldehyde 3-phosphate reductase -
PUP58_RS02445 (PUP58_02445) 543927..544355 - 429 WP_009046452.1 type II toxin-antitoxin system VapC family toxin -
PUP58_RS02450 (PUP58_02450) 544352..544597 - 246 WP_009046453.1 plasmid stabilization protein -
PUP58_RS02455 (PUP58_02455) 544737..545576 - 840 WP_009046454.1 taurine dioxygenase -
PUP58_RS02460 (PUP58_02460) 545812..546651 - 840 WP_009046455.1 taurine ABC transporter permease TauC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6933.08 Da        Isoelectric Point: 10.4588

>T272855 WP_009041685.1 NZ_CP118148:541577-541759 [Pseudomonas chlororaphis]
MRSRELIRMIEEDGWYLIAVKGSHHQYKHLHKPGRVTIPHPDADLPRGTIHSILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14596.44 Da        Isoelectric Point: 4.9133

>AT272855 WP_009046450.1 NZ_CP118148:541789-542190 [Pseudomonas chlororaphis]
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAQAFENVKEALSLHYEGLVADGEPLPQVHEVDVHIDNPDYAGGVWGVI
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285EYZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A554PT90

References