Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 563616..564229 Replicon chromosome
Accession NZ_CP118147
Organism Pseudomonas chlororaphis strain ATCC 174151

Toxin (Protein)


Gene name hicA Uniprot ID A0A285EYZ4
Locus tag PUP56_RS02525 Protein ID WP_009041685.1
Coordinates 563616..563798 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2N8BII0
Locus tag PUP56_RS02530 Protein ID WP_009041686.1
Coordinates 563828..564229 (+) Length 134 a.a.

Genomic Context


PUP56_RS02520PUP56_RS02525PUP56_RS02530PUP56_RS02540PUP56_RS02545PUP56_RS02495PUP56_RS02500PUP56_RS02505PUP56_RS02510PUP56_RS02515PUP56_RS02535
Location: 562601..563491 (891 bp)
Type: Others
Protein ID: WP_053259258.1
Location: 563616..563798 (183 bp)
Type: Toxin
Protein ID: WP_009041685.1
Location: 563828..564229 (402 bp)
Type: Antitoxin
Protein ID: WP_009041686.1
Location: 565572..567830 (2259 bp)
Type: Others
Protein ID: WP_114760181.1
Location: 567877..569202 (1326 bp)
Type: Others
Protein ID: WP_009041689.1
Location: 559381..559638 (258 bp)
Type: Others
Protein ID: WP_062824009.1
Location: 559691..560179 (489 bp)
Type: Others
Protein ID: WP_009041680.1
Location: 560253..561149 (897 bp)
Type: Others
Protein ID: WP_114760179.1
Location: 561179..561688 (510 bp)
Type: Others
Protein ID: WP_009041682.1
Location: 561722..562462 (741 bp)
Type: Others
Protein ID: WP_053259257.1
Location: 564318..565364 (1047 bp)
Type: Others
Protein ID: WP_114760180.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PUP56_RS02495 (PUP56_02495)559381..559638-258WP_062824009.1hypothetical protein-
PUP56_RS02500 (PUP56_02500)559691..560179-489WP_009041680.1DoxX family protein-
PUP56_RS02505 (PUP56_02505)560253..561149-897WP_114760179.1SDR family oxidoreductase-
PUP56_RS02510 (PUP56_02510)561179..561688-510WP_009041682.1DUF1097 domain-containing protein-
PUP56_RS02515 (PUP56_02515)561722..562462-741WP_053259257.1SDR family oxidoreductase-
PUP56_RS02520 (PUP56_02520)562601..563491+891WP_053259258.1LysR family transcriptional regulator-
PUP56_RS02525 (PUP56_02525)563616..563798+183WP_009041685.1type II toxin-antitoxin system HicA family toxinToxin
PUP56_RS02530 (PUP56_02530)563828..564229+402WP_009041686.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
PUP56_RS02535 (PUP56_02535)564318..565364-1047WP_114760180.1LacI family DNA-binding transcriptional regulator-
PUP56_RS02540 (PUP56_02540)565572..567830+2259WP_114760181.1TonB-dependent receptor-
PUP56_RS02545 (PUP56_02545)567877..569202+1326WP_009041689.1LLM class flavin-dependent oxidoreductase-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 61 a.a.        Molecular weight: 6933.08 Da        Isoelectric Point: 10.4588

>T272848 WP_009041685.1 NZ_CP118147:563616-563798 [Pseudomonas chlororaphis]
MRSRELIRMIEEDGWYLIAVKGSHHQYKHLHKPGRVTIPHPDADLPRGTIHSILKQAGLK

Download         Length: 183 bp


Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14629.48 Da        Isoelectric Point: 4.7569

>AT272848 WP_009041686.1 NZ_CP118147:563828-564229 [Pseudomonas chlororaphis]
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAEAFENVKEALSLHYEGLVADGEPLPQVHEVDVHIDNPDYAGGVWGMI
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA

Download         Length: 402 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A285EYZ4


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2N8BII0

References