Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 118275..119983 Replicon chromosome
Accession NZ_CP118147
Organism Pseudomonas chlororaphis strain ATCC 174151

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag PUP56_RS00580 Protein ID WP_114761240.1
Coordinates 118275..119153 (+) Length 293 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A5M7C4U8
Locus tag PUP56_RS00585 Protein ID WP_007928502.1
Coordinates 119150..119983 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP56_RS00555 (PUP56_00555) 114283..115119 + 837 WP_223816097.1 ABC transporter ATP-binding protein -
PUP56_RS00560 (PUP56_00560) 115159..116148 + 990 WP_114761241.1 ABC transporter substrate-binding protein -
PUP56_RS00565 (PUP56_00565) 116177..116953 + 777 WP_007928506.1 ABC transporter permease -
PUP56_RS00570 (PUP56_00570) 116953..117717 + 765 WP_101336297.1 SDR family oxidoreductase -
PUP56_RS00575 (PUP56_00575) 117731..118270 + 540 WP_085532783.1 cupin domain-containing protein -
PUP56_RS00580 (PUP56_00580) 118275..119153 + 879 WP_114761240.1 alpha/beta hydrolase Toxin
PUP56_RS00585 (PUP56_00585) 119150..119983 + 834 WP_007928502.1 IclR family transcriptional regulator Antitoxin
PUP56_RS00590 (PUP56_00590) 119985..120782 + 798 WP_114761239.1 SDR family oxidoreductase -
PUP56_RS00595 (PUP56_00595) 120775..122457 + 1683 WP_114761268.1 thiamine pyrophosphate-binding protein -
PUP56_RS00600 (PUP56_00600) 122468..123271 + 804 WP_085532775.1 aspartate dehydrogenase -
PUP56_RS00605 (PUP56_00605) 123283..124779 + 1497 WP_114761238.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(45-276)

Antitoxin

Transcription regulator IclR, C-terminal

(136-256)


Sequences

Toxin        


Download         Length: 293 a.a.        Molecular weight: 31023.53 Da        Isoelectric Point: 8.0027

>T272847 WP_114761240.1 NZ_CP118147:118275-119153 [Pseudomonas chlororaphis]
MLPGLSQPVSTADLQARLTRDFAQRQVTVAGGRQALRECGAGPAIVLLHGIGSGAASWLQVAQQLAPQARVIAWDAPGYG
DSSPLESPAPKAEHYAARLVQMLDALDVEECVLVGHSLGALPALAFARSSQASRVSRLVLISPARGYGAPERGEQRQQVR
RQRLENLEHLGITGLAEQRSTHMLSPNAAPQALAWVRWNMARLNPAGYRQAIELLCGGDLLRHGQPGMPCEVHCGEADRI
TPAETCLTLAKALGASFNLIADAGHASPIEQPLVVAGRLAFAIKESLTGRTL

Download         Length: 879 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30869.31 Da        Isoelectric Point: 6.6493

>AT272847 WP_007928502.1 NZ_CP118147:119150-119983 [Pseudomonas chlororaphis]
MNDSDPLKDAQDKYIVPGLERGLLLLCEFSRRNRTLTAPELARRLALPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDRLNYPSNLVVRDGRSIVYVAKVSPPSVFSNAVNVGTRLPAHATVLGRILLEDLSLA
ELRELYPEEHLEQYSHSTPKTVLELFDMVQADRQRGFISGEGFFESAISTVAAPVRDQSGRIAAALGVTIPTTQIGHVNF
EELLSQVRRSADELSRLLNYNGVAHDGQQRVTALMRD

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5M7C4U8

References