Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 6112213..6112802 Replicon chromosome
Accession NZ_CP118146
Organism Pseudomonas chlororaphis strain ATCC 174152

Toxin (Protein)


Gene name PumA Uniprot ID A0A285IHJ3
Locus tag PUP66_RS27565 Protein ID WP_062824477.1
Coordinates 6112503..6112802 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag PUP66_RS27560 Protein ID WP_007924096.1
Coordinates 6112213..6112506 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP66_RS27535 (PUP66_27535) 6107926..6108384 + 459 WP_009045805.1 GNAT family N-acetyltransferase -
PUP66_RS27540 (PUP66_27540) 6108638..6109294 + 657 WP_007924093.1 DedA family protein -
PUP66_RS27545 (PUP66_27545) 6109300..6110109 + 810 WP_062824480.1 zinc-dependent peptidase -
PUP66_RS27550 (PUP66_27550) 6110374..6110901 + 528 WP_114761534.1 inorganic diphosphatase -
PUP66_RS27555 (PUP66_27555) 6111716..6112097 + 382 Protein_5430 DUF3077 domain-containing protein -
PUP66_RS27560 (PUP66_27560) 6112213..6112506 - 294 WP_007924096.1 putative addiction module antidote protein Antitoxin
PUP66_RS27565 (PUP66_27565) 6112503..6112802 - 300 WP_062824477.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PUP66_RS27570 (PUP66_27570) 6112974..6113423 + 450 WP_009045812.1 DUF3828 domain-containing protein -
PUP66_RS27575 (PUP66_27575) 6113448..6114458 - 1011 WP_205350727.1 NAD(P)-dependent alcohol dehydrogenase -
PUP66_RS27580 (PUP66_27580) 6114516..6114815 - 300 WP_007924100.1 helix-turn-helix transcriptional regulator -
PUP66_RS27585 (PUP66_27585) 6114883..6115971 - 1089 WP_062824475.1 copper-containing nitrite reductase -
PUP66_RS27590 (PUP66_27590) 6116197..6116439 + 243 WP_007924102.1 exodeoxyribonuclease VII small subunit -
PUP66_RS27595 (PUP66_27595) 6116436..6117323 + 888 WP_053262814.1 (2E,6E)-farnesyl diphosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-94)

Antitoxin

Uncharacterized protein HI1420

(6-91)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11261.01 Da        Isoelectric Point: 10.8652

>T272846 WP_062824477.1 NZ_CP118146:c6112802-6112503 [Pseudomonas chlororaphis]
MIEIKQTATFMEWENRLKDSRARALIAARIFRLANGLAGDVSPVGEGVSELRIHYGPGYRVYFQQRGLQLVILLCGGDKS
RQGRDIELAKQLARRWSRS

Download         Length: 300 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10430.94 Da        Isoelectric Point: 5.6558

>AT272846 WP_007924096.1 NZ_CP118146:c6112506-6112213 [Pseudomonas chlororaphis]
MNEPLFDYDPATALRDPQAIALFMADAFETGDAGYIAKALGVVARAKGMTELAHETGLSREQLYRSFSDKGNPTLKTLLA
VMRALGLDMTARVHGAS

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285IHJ3

Antitoxin

Source ID Structure

References