Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2551468..2552053 Replicon chromosome
Accession NZ_CP118146
Organism Pseudomonas chlororaphis strain ATCC 174152

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag PUP66_RS11680 Protein ID WP_085530375.1
Coordinates 2551760..2552053 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A285IMN7
Locus tag PUP66_RS11675 Protein ID WP_009043099.1
Coordinates 2551468..2551758 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP66_RS11665 (PUP66_11665) 2548983..2550365 + 1383 WP_114761927.1 efflux transporter outer membrane subunit -
PUP66_RS11670 (PUP66_11670) 2550484..2551071 + 588 WP_007923530.1 hypothetical protein -
PUP66_RS11675 (PUP66_11675) 2551468..2551758 - 291 WP_009043099.1 putative addiction module antidote protein Antitoxin
PUP66_RS11680 (PUP66_11680) 2551760..2552053 - 294 WP_085530375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PUP66_RS11685 (PUP66_11685) 2552289..2553683 - 1395 WP_114761928.1 VOC family protein -
PUP66_RS11690 (PUP66_11690) 2553948..2555072 + 1125 WP_114761929.1 diguanylate cyclase -
PUP66_RS11695 (PUP66_11695) 2555166..2556410 + 1245 WP_114761930.1 M20/M25/M40 family metallo-hydrolase -
PUP66_RS11700 (PUP66_11700) 2556643..2557038 + 396 WP_114761931.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-96)

Antitoxin

Uncharacterized protein HI1420

(9-94)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10736.34 Da        Isoelectric Point: 10.0960

>T272845 WP_085530375.1 NZ_CP118146:c2552053-2551760 [Pseudomonas chlororaphis]
MDYEILQTTVFAQWHTTLRDLRARIAIARRIERASAGNLGDVKNLGGGLSEMRVNTGAGYRLYFTVRGHTLIVLLLGGDK
STQPADICQARSLAKEF

Download         Length: 294 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10223.78 Da        Isoelectric Point: 8.0096

>AT272845 WP_009043099.1 NZ_CP118146:c2551758-2551468 [Pseudomonas chlororaphis]
MSDTLLPFDIAALLDSDQAISEYLSQVLADGDTDELIRALGHVARARGMTQIAKATGQGRASLYKAFAPGAKPRFDTVVK
VMRALGLQLCTTVSRG

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A285IMN7

References