Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1424596..1425427 Replicon chromosome
Accession NC_017632
Organism Escherichia coli UM146

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag UM146_RS06975 Protein ID WP_000854814.1
Coordinates 1424596..1424970 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag UM146_RS06980 Protein ID WP_001285586.1
Coordinates 1425059..1425427 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UM146_RS06940 1419993..1421158 + 1166 Protein_1324 serine-type D-Ala-D-Ala carboxypeptidase DacD -
UM146_RS06945 1421277..1421750 + 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
UM146_RS06950 1421948..1423006 + 1059 WP_001200890.1 FUSC family protein -
UM146_RS06955 1423178..1423507 + 330 WP_000450409.1 DUF496 family protein -
UM146_RS26045 1423608..1423790 - 183 WP_001016348.1 hypothetical protein -
UM146_RS27840 1423844..1423990 + 147 Protein_1329 transposase domain-containing protein -
UM146_RS29065 1424279..1424392 - 114 WP_001161660.1 DUF957 domain-containing protein -
UM146_RS06970 1424405..1424599 - 195 WP_000988601.1 hypothetical protein -
UM146_RS06975 1424596..1424970 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
UM146_RS06980 1425059..1425427 - 369 WP_001285586.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
UM146_RS06985 1425501..1425722 - 222 WP_000692323.1 DUF987 domain-containing protein -
UM146_RS06990 1425791..1426267 - 477 WP_001298074.1 RadC family protein -
UM146_RS06995 1426282..1426755 - 474 WP_000855071.1 antirestriction protein -
UM146_RS07000 1427018..1427839 - 822 WP_001234570.1 DUF945 domain-containing protein -
UM146_RS07005 1428060..1428470 - 411 WP_000846704.1 hypothetical protein -
UM146_RS07010 1428486..1429163 - 678 WP_001362823.1 hypothetical protein -
UM146_RS07015 1429299..1430369 - 1071 WP_000102631.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T27284 WP_000854814.1 NC_017632:c1424970-1424596 [Escherichia coli UM146]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T27284 NC_017632:c1424970-1424596 [Escherichia coli UM146]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT27284 WP_001285586.1 NC_017632:c1425427-1425059 [Escherichia coli UM146]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT27284 NC_017632:c1425427-1425059 [Escherichia coli UM146]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References