Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2535136..2535755 Replicon chromosome
Accession NZ_CP118145
Organism Pseudomonas chlororaphis strain ATCC 17417

Toxin (Protein)


Gene name hicA Uniprot ID A0A285IZB4
Locus tag PUP75_RS11655 Protein ID WP_009043086.1
Coordinates 2535573..2535755 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PUP75_RS11650 Protein ID WP_053278311.1
Coordinates 2535136..2535537 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP75_RS11640 (PUP75_11640) 2532971..2533621 - 651 WP_274336207.1 hypothetical protein -
PUP75_RS11645 (PUP75_11645) 2533919..2534683 + 765 WP_097140360.1 hypothetical protein -
PUP75_RS11650 (PUP75_11650) 2535136..2535537 - 402 WP_053278311.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP75_RS11655 (PUP75_11655) 2535573..2535755 - 183 WP_009043086.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP75_RS11660 (PUP75_11660) 2536119..2536400 - 282 WP_009043087.1 hypothetical protein -
PUP75_RS11665 (PUP75_11665) 2536964..2538031 + 1068 WP_114761923.1 DUF4263 domain-containing protein -
PUP75_RS11670 (PUP75_11670) 2538190..2538738 - 549 WP_274336208.1 YniB family protein -
PUP75_RS11675 (PUP75_11675) 2538880..2539035 + 156 Protein_2294 TonB-dependent receptor -
PUP75_RS11680 (PUP75_11680) 2539221..2539874 + 654 WP_085530371.1 peroxiredoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6800.02 Da        Isoelectric Point: 11.0738

>T272838 WP_009043086.1 NZ_CP118145:c2535755-2535573 [Pseudomonas chlororaphis]
VQSRQLIKELEAAGWVLERVTGSHHLFKHPYRPETVPVPHPKKDLPRGTVRAIKKLAGLI

Download         Length: 183 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14591.59 Da        Isoelectric Point: 4.6017

>AT272838 WP_053278311.1 NZ_CP118145:c2535537-2535136 [Pseudomonas chlororaphis]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAIEIAHVMLEELAREGQAIPLPSPTGIHRANPDFEGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQRIDRFVREHNIKSRSSFLADAAMEKLGR

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285IZB4

Antitoxin

Source ID Structure

References