Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 540052..540665 Replicon chromosome
Accession NZ_CP118145
Organism Pseudomonas chlororaphis strain ATCC 17417

Toxin (Protein)


Gene name hicA Uniprot ID A0A285EYZ4
Locus tag PUP75_RS02430 Protein ID WP_009041685.1
Coordinates 540052..540234 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2N8BII0
Locus tag PUP75_RS02435 Protein ID WP_009041686.1
Coordinates 540264..540665 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP75_RS02400 (PUP75_02400) 535817..536074 - 258 WP_009041679.1 hypothetical protein -
PUP75_RS02405 (PUP75_02405) 536127..536615 - 489 WP_009041680.1 DoxX family protein -
PUP75_RS02410 (PUP75_02410) 536689..537585 - 897 WP_274335605.1 SDR family oxidoreductase -
PUP75_RS02415 (PUP75_02415) 537615..538124 - 510 WP_274335606.1 DUF1097 domain-containing protein -
PUP75_RS02420 (PUP75_02420) 538158..538898 - 741 WP_053259257.1 SDR family oxidoreductase -
PUP75_RS02425 (PUP75_02425) 539037..539927 + 891 WP_123411910.1 LysR family transcriptional regulator -
PUP75_RS02430 (PUP75_02430) 540052..540234 + 183 WP_009041685.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP75_RS02435 (PUP75_02435) 540264..540665 + 402 WP_009041686.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP75_RS02440 (PUP75_02440) 540754..541800 - 1047 WP_085533366.1 LacI family DNA-binding transcriptional regulator -
PUP75_RS02445 (PUP75_02445) 542008..544266 + 2259 WP_274335607.1 TonB-dependent receptor -
PUP75_RS02450 (PUP75_02450) 544313..545638 + 1326 WP_009041689.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6933.08 Da        Isoelectric Point: 10.4588

>T272834 WP_009041685.1 NZ_CP118145:540052-540234 [Pseudomonas chlororaphis]
MRSRELIRMIEEDGWYLIAVKGSHHQYKHLHKPGRVTIPHPDADLPRGTIHSILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14629.48 Da        Isoelectric Point: 4.7569

>AT272834 WP_009041686.1 NZ_CP118145:540264-540665 [Pseudomonas chlororaphis]
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAEAFENVKEALSLHYEGLVADGEPLPQVHEVDVHIDNPDYAGGVWGMI
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285EYZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A2N8BII0

References