Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1777519..1778141 Replicon chromosome
Accession NZ_CP118144
Organism Pseudomonas chlororaphis strain ATCC 174181

Toxin (Protein)


Gene name hicA Uniprot ID A0A285HEJ8
Locus tag PUP51_RS08020 Protein ID WP_053259927.1
Coordinates 1777959..1778141 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A285HET1
Locus tag PUP51_RS08015 Protein ID WP_009042564.1
Coordinates 1777519..1777926 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP51_RS07995 (PUP51_07995) 1772693..1773355 - 663 WP_274332166.1 NAD(P)-binding domain-containing protein -
PUP51_RS08000 (PUP51_08000) 1773458..1774348 + 891 WP_274333654.1 LysR family transcriptional regulator -
PUP51_RS08005 (PUP51_08005) 1774587..1776365 + 1779 WP_274332168.1 GGDEF and EAL domain-containing protein -
PUP51_RS08010 (PUP51_08010) 1776399..1777313 - 915 WP_274332170.1 SGNH/GDSL hydrolase family protein -
PUP51_RS08015 (PUP51_08015) 1777519..1777926 - 408 WP_009042564.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP51_RS08020 (PUP51_08020) 1777959..1778141 - 183 WP_053259927.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP51_RS08030 (PUP51_08030) 1778863..1779747 - 885 WP_009042569.1 alpha/beta hydrolase -
PUP51_RS08035 (PUP51_08035) 1780099..1780791 - 693 WP_062823358.1 16S rRNA pseudouridine(516) synthase -
PUP51_RS08040 (PUP51_08040) 1780825..1781043 - 219 WP_274333656.1 cysteine-rich CWC family protein -
PUP51_RS08045 (PUP51_08045) 1781051..1782538 - 1488 WP_274332174.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6873.18 Da        Isoelectric Point: 11.1084

>T272830 WP_053259927.1 NZ_CP118144:c1778141-1777959 [Pseudomonas chlororaphis]
VDSRYLIGQIVADGWYLVRVRGSHHHFKHPHKPGLVTVPHPKKDLLRKTAISILKQALLM

Download         Length: 183 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14698.72 Da        Isoelectric Point: 4.5911

>AT272830 WP_009042564.1 NZ_CP118144:c1777926-1777519 [Pseudomonas chlororaphis]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGAPIPHANKVTLHAANPRYAGCTWAL
IDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285HEJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A285HET1

References