Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 1777502..1778124 | Replicon | chromosome |
Accession | NZ_CP118143 | ||
Organism | Pseudomonas chlororaphis strain ATCC 174182 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | A0A285HEJ8 |
Locus tag | PUP62_RS08020 | Protein ID | WP_053259927.1 |
Coordinates | 1777942..1778124 (-) | Length | 61 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A285HET1 |
Locus tag | PUP62_RS08015 | Protein ID | WP_009042564.1 |
Coordinates | 1777502..1777909 (-) | Length | 136 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PUP62_RS07995 (PUP62_07995) | 1772676..1773338 | - | 663 | WP_274332166.1 | NAD(P)-binding domain-containing protein | - |
PUP62_RS08000 (PUP62_08000) | 1773441..1774331 | + | 891 | WP_274333654.1 | LysR family transcriptional regulator | - |
PUP62_RS08005 (PUP62_08005) | 1774570..1776348 | + | 1779 | WP_274332168.1 | GGDEF and EAL domain-containing protein | - |
PUP62_RS08010 (PUP62_08010) | 1776382..1777296 | - | 915 | WP_274332170.1 | SGNH/GDSL hydrolase family protein | - |
PUP62_RS08015 (PUP62_08015) | 1777502..1777909 | - | 408 | WP_009042564.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
PUP62_RS08020 (PUP62_08020) | 1777942..1778124 | - | 183 | WP_053259927.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
PUP62_RS08030 (PUP62_08030) | 1778846..1779730 | - | 885 | WP_009042569.1 | alpha/beta hydrolase | - |
PUP62_RS08035 (PUP62_08035) | 1780082..1780774 | - | 693 | WP_062823358.1 | 16S rRNA pseudouridine(516) synthase | - |
PUP62_RS08040 (PUP62_08040) | 1780808..1781026 | - | 219 | WP_274333656.1 | cysteine-rich CWC family protein | - |
PUP62_RS08045 (PUP62_08045) | 1781034..1782521 | - | 1488 | WP_274332174.1 | sensor domain-containing diguanylate cyclase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6873.18 Da Isoelectric Point: 11.1084
>T272822 WP_053259927.1 NZ_CP118143:c1778124-1777942 [Pseudomonas chlororaphis]
VDSRYLIGQIVADGWYLVRVRGSHHHFKHPHKPGLVTVPHPKKDLLRKTAISILKQALLM
VDSRYLIGQIVADGWYLVRVRGSHHHFKHPHKPGLVTVPHPKKDLLRKTAISILKQALLM
Download Length: 183 bp
Antitoxin
Download Length: 136 a.a. Molecular weight: 14698.72 Da Isoelectric Point: 4.5911
>AT272822 WP_009042564.1 NZ_CP118143:c1777909-1777502 [Pseudomonas chlororaphis]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGAPIPHANKVTLHAANPRYAGCTWAL
IDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGAPIPHANKVTLHAANPRYAGCTWAL
IDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD
Download Length: 408 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A285HEJ8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A285HET1 |