272818

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 552704..553317 Replicon chromosome
Accession NZ_CP118143
Organism Pseudomonas chlororaphis strain ATCC 174182

Toxin (Protein)


Gene name hicA Uniprot ID A0A285EYZ4
Locus tag PUP62_RS02460 Protein ID WP_009041685.1
Coordinates 552704..552886 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2N8BII0
Locus tag PUP62_RS02465 Protein ID WP_009041686.1
Coordinates 552916..553317 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP62_RS02430 (PUP62_02430) 548460..548717 - 258 WP_009041679.1 hypothetical protein -
PUP62_RS02435 (PUP62_02435) 548770..549258 - 489 WP_009041680.1 DoxX family protein -
PUP62_RS02440 (PUP62_02440) 549332..550237 - 906 WP_274331315.1 SDR family oxidoreductase -
PUP62_RS02445 (PUP62_02445) 550267..550776 - 510 WP_274331317.1 DUF1097 domain-containing protein -
PUP62_RS02450 (PUP62_02450) 550810..551550 - 741 WP_009041683.1 SDR family oxidoreductase -
PUP62_RS02455 (PUP62_02455) 551689..552579 + 891 WP_053259258.1 LysR family transcriptional regulator -
PUP62_RS02460 (PUP62_02460) 552704..552886 + 183 WP_009041685.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP62_RS02465 (PUP62_02465) 552916..553317 + 402 WP_009041686.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP62_RS02470 (PUP62_02470) 553405..554451 - 1047 WP_114760180.1 LacI family DNA-binding transcriptional regulator -
PUP62_RS02475 (PUP62_02475) 554659..556917 + 2259 WP_274331319.1 TonB-dependent receptor -
PUP62_RS02480 (PUP62_02480) 556964..558289 + 1326 WP_274331320.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6933.08 Da        Isoelectric Point: 10.4588

>T272818 WP_009041685.1 NZ_CP118143:552704-552886 [Pseudomonas chlororaphis]
MRSRELIRMIEEDGWYLIAVKGSHHQYKHLHKPGRVTIPHPDADLPRGTIHSILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14629.48 Da        Isoelectric Point: 4.7569

>AT272818 WP_009041686.1 NZ_CP118143:552916-553317 [Pseudomonas chlororaphis]
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAEAFENVKEALSLHYEGLVADGEPLPQVHEVDVHIDNPDYAGGVWGMI
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285EYZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A2N8BII0

References