Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5786771..5787393 Replicon chromosome
Accession NZ_CP118142
Organism Pseudomonas chlororaphis strain ATCC 17809

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PUP81_RS26180 Protein ID WP_106696706.1
Coordinates 5786771..5786953 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PUP81_RS26185 Protein ID WP_106698998.1
Coordinates 5786986..5787393 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP81_RS26155 (PUP81_26155) 5782377..5783864 + 1488 WP_106696708.1 sensor domain-containing diguanylate cyclase -
PUP81_RS26160 (PUP81_26160) 5783872..5784090 + 219 WP_274346761.1 cysteine-rich CWC family protein -
PUP81_RS26165 (PUP81_26165) 5784124..5784816 + 693 WP_025804997.1 16S rRNA pseudouridine(516) synthase -
PUP81_RS26170 (PUP81_26170) 5785168..5786052 + 885 WP_009047472.1 alpha/beta hydrolase -
PUP81_RS26180 (PUP81_26180) 5786771..5786953 + 183 WP_106696706.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP81_RS26185 (PUP81_26185) 5786986..5787393 + 408 WP_106698998.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP81_RS26190 (PUP81_26190) 5787639..5788106 + 468 WP_106696705.1 GAF domain-containing protein -
PUP81_RS26195 (PUP81_26195) 5788236..5789150 + 915 WP_124323665.1 SGNH/GDSL hydrolase family protein -
PUP81_RS26200 (PUP81_26200) 5789184..5790962 - 1779 WP_124323664.1 GGDEF and EAL domain-containing protein -
PUP81_RS26205 (PUP81_26205) 5791198..5792091 - 894 WP_173678573.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6810.12 Da        Isoelectric Point: 11.6709

>T272815 WP_106696706.1 NZ_CP118142:5786771-5786953 [Pseudomonas chlororaphis]
VNSRYLIGQIVADGWYLVRVRGSHHPFRHPSKPGLVTVPHPKKDLLRKTAISILKQALLM

Download         Length: 183 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14657.65 Da        Isoelectric Point: 4.4710

>AT272815 WP_106698998.1 NZ_CP118142:5786986-5787393 [Pseudomonas chlororaphis]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGAAIPPANKVTLHAANPQYAGRTWAL
IDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References