272814

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4957041..4957660 Replicon chromosome
Accession NZ_CP118142
Organism Pseudomonas chlororaphis strain ATCC 17809

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G7DMG3
Locus tag PUP81_RS22430 Protein ID WP_009048155.1
Coordinates 4957041..4957223 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A285IZU0
Locus tag PUP81_RS22435 Protein ID WP_007923747.1
Coordinates 4957259..4957660 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP81_RS22415 (PUP81_22415) 4952776..4953324 + 549 WP_124304749.1 YniB family protein -
PUP81_RS22420 (PUP81_22420) 4953665..4955824 + 2160 WP_164486009.1 AAA family ATPase -
PUP81_RS22425 (PUP81_22425) 4956468..4956749 + 282 WP_124304747.1 hypothetical protein -
PUP81_RS22430 (PUP81_22430) 4957041..4957223 + 183 WP_009048155.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP81_RS22435 (PUP81_22435) 4957259..4957660 + 402 WP_007923747.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP81_RS22440 (PUP81_22440) 4958226..4958975 - 750 WP_124304746.1 hypothetical protein -
PUP81_RS22445 (PUP81_22445) 4959069..4959704 - 636 WP_124304745.1 response regulator transcription factor -
PUP81_RS22450 (PUP81_22450) 4959701..4961590 - 1890 WP_124304744.1 PAS domain S-box protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6799.98 Da        Isoelectric Point: 10.9678

>T272814 WP_009048155.1 NZ_CP118142:4957041-4957223 [Pseudomonas chlororaphis]
VQSRQLIKELEAAGWVLERVTGSHHLFKHPYRPETVPVPHPKKDLPRGTVRAIQKLAGLI

Download         Length: 183 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14579.54 Da        Isoelectric Point: 4.6017

>AT272814 WP_007923747.1 NZ_CP118142:4957259-4957660 [Pseudomonas chlororaphis]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAIEIAHVMLEELAREGQAIPLPSPTGTHRANPDFEGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQRIDRFVREHNIKSRSSFLADAAMEKLGR

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G7DMG3

Antitoxin

Source ID Structure
AlphaFold DB A0A285IZU0

References