Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1772510..1773132 Replicon chromosome
Accession NZ_CP118141
Organism Pseudomonas chlororaphis strain ATCC 17814

Toxin (Protein)


Gene name hicA Uniprot ID A0A285HEJ8
Locus tag PUP70_RS08015 Protein ID WP_053259927.1
Coordinates 1772950..1773132 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A285HET1
Locus tag PUP70_RS08010 Protein ID WP_009042564.1
Coordinates 1772510..1772917 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP70_RS07990 (PUP70_07990) 1767685..1768347 - 663 WP_053259924.1 NAD(P)-binding domain-containing protein -
PUP70_RS07995 (PUP70_07995) 1768450..1769340 + 891 WP_053260051.1 LysR family transcriptional regulator -
PUP70_RS08000 (PUP70_08000) 1769578..1771356 + 1779 WP_053259925.1 sensor domain-containing phosphodiesterase -
PUP70_RS08005 (PUP70_08005) 1771390..1772304 - 915 WP_053259926.1 SGNH/GDSL hydrolase family protein -
PUP70_RS08010 (PUP70_08010) 1772510..1772917 - 408 WP_009042564.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP70_RS08015 (PUP70_08015) 1772950..1773132 - 183 WP_053259927.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP70_RS08020 (PUP70_08020) 1774196..1774912 + 717 WP_053259928.1 molecular chaperone -
PUP70_RS08025 (PUP70_08025) 1775023..1775982 + 960 WP_053259929.1 fimbrial protein -
PUP70_RS08030 (PUP70_08030) 1776106..1776666 + 561 Protein_1583 HipA domain-containing protein -
PUP70_RS08035 (PUP70_08035) 1776781..1777524 - 744 WP_053259931.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6873.18 Da        Isoelectric Point: 11.1084

>T272809 WP_053259927.1 NZ_CP118141:c1773132-1772950 [Pseudomonas chlororaphis]
VDSRYLIGQIVADGWYLVRVRGSHHHFKHPHKPGLVTVPHPKKDLLRKTAISILKQALLM

Download         Length: 183 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14698.72 Da        Isoelectric Point: 4.5911

>AT272809 WP_009042564.1 NZ_CP118141:c1772917-1772510 [Pseudomonas chlororaphis]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGAPIPHANKVTLHAANPRYAGCTWAL
IDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285HEJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A285HET1

References