Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2522043..2522662 Replicon chromosome
Accession NZ_CP118140
Organism Pseudomonas chlororaphis strain ATCC 336632

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PUP57_RS11490 Protein ID WP_081363244.1
Coordinates 2522480..2522662 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A285IZU0
Locus tag PUP57_RS11485 Protein ID WP_007923747.1
Coordinates 2522043..2522444 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP57_RS11470 (PUP57_11470) 2517933..2519822 + 1890 WP_081362143.1 PAS domain S-box protein -
PUP57_RS11475 (PUP57_11475) 2519819..2520454 + 636 WP_081362142.1 response regulator transcription factor -
PUP57_RS11480 (PUP57_11480) 2520548..2521297 + 750 WP_081362141.1 hypothetical protein -
PUP57_RS11485 (PUP57_11485) 2522043..2522444 - 402 WP_007923747.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP57_RS11490 (PUP57_11490) 2522480..2522662 - 183 WP_081363244.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP57_RS11495 (PUP57_11495) 2522954..2523235 - 282 WP_081362140.1 hypothetical protein -
PUP57_RS11500 (PUP57_11500) 2523658..2524035 - 378 WP_081362139.1 hypothetical protein -
PUP57_RS11505 (PUP57_11505) 2524788..2525699 + 912 WP_124344721.1 hypothetical protein -
PUP57_RS11510 (PUP57_11510) 2526021..2526497 - 477 WP_081362137.1 TIGR02391 family protein -
PUP57_RS11515 (PUP57_11515) 2526481..2527191 - 711 WP_124344722.1 DUF5343 domain-containing protein -
PUP57_RS11520 (PUP57_11520) 2527314..2527424 + 111 Protein_2263 serine recombinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6759.96 Da        Isoelectric Point: 10.9678

>T272802 WP_081363244.1 NZ_CP118140:c2522662-2522480 [Pseudomonas chlororaphis]
VQSRQLIKELEAAGWVLERVTGSHHLFKPPYRPETVPVPHPKKDLPRGTVRAIQKLAGLI

Download         Length: 183 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14579.54 Da        Isoelectric Point: 4.6017

>AT272802 WP_007923747.1 NZ_CP118140:c2522444-2522043 [Pseudomonas chlororaphis]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAIEIAHVMLEELAREGQAIPLPSPTGTHRANPDFEGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQRIDRFVREHNIKSRSSFLADAAMEKLGR

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A285IZU0

References