Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 554304..554917 Replicon chromosome
Accession NZ_CP118140
Organism Pseudomonas chlororaphis strain ATCC 336632

Toxin (Protein)


Gene name hicA Uniprot ID A0A285EYZ4
Locus tag PUP57_RS02465 Protein ID WP_009041685.1
Coordinates 554304..554486 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A554PT90
Locus tag PUP57_RS02470 Protein ID WP_009046450.1
Coordinates 554516..554917 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP57_RS02435 (PUP57_02435) 550070..550327 - 258 WP_009046444.1 hypothetical protein -
PUP57_RS02440 (PUP57_02440) 550380..550868 - 489 WP_028683850.1 DoxX family protein -
PUP57_RS02445 (PUP57_02445) 550942..551838 - 897 WP_081362987.1 SDR family oxidoreductase -
PUP57_RS02450 (PUP57_02450) 551867..552376 - 510 WP_081362986.1 DUF1097 domain-containing protein -
PUP57_RS02455 (PUP57_02455) 552410..553150 - 741 WP_081362985.1 SDR family oxidoreductase -
PUP57_RS02460 (PUP57_02460) 553289..554179 + 891 WP_081362984.1 LysR family transcriptional regulator -
PUP57_RS02465 (PUP57_02465) 554304..554486 + 183 WP_009041685.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP57_RS02470 (PUP57_02470) 554516..554917 + 402 WP_009046450.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP57_RS02475 (PUP57_02475) 555017..556063 - 1047 WP_081362983.1 LacI family DNA-binding transcriptional regulator -
PUP57_RS02480 (PUP57_02480) 556271..558529 + 2259 WP_081362982.1 TonB-dependent receptor -
PUP57_RS02485 (PUP57_02485) 558576..559901 + 1326 WP_081362981.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6933.08 Da        Isoelectric Point: 10.4588

>T272800 WP_009041685.1 NZ_CP118140:554304-554486 [Pseudomonas chlororaphis]
MRSRELIRMIEEDGWYLIAVKGSHHQYKHLHKPGRVTIPHPDADLPRGTIHSILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14596.44 Da        Isoelectric Point: 4.9133

>AT272800 WP_009046450.1 NZ_CP118140:554516-554917 [Pseudomonas chlororaphis]
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAQAFENVKEALSLHYEGLVADGEPLPQVHEVDVHIDNPDYAGGVWGVI
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285EYZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A554PT90

References