Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1833521..1834143 Replicon chromosome
Accession NZ_CP118139
Organism Pseudomonas chlororaphis strain DSM 295781

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PUP68_RS08375 Protein ID WP_053277798.1
Coordinates 1833961..1834143 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PUP68_RS08370 Protein ID WP_053277797.1
Coordinates 1833521..1833928 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP68_RS08350 (PUP68_08350) 1828881..1829771 + 891 WP_274320933.1 LysR family transcriptional regulator -
PUP68_RS08355 (PUP68_08355) 1830008..1831786 + 1779 WP_053277794.1 GGDEF and EAL domain-containing protein -
PUP68_RS08360 (PUP68_08360) 1831820..1832734 - 915 WP_274320932.1 SGNH/GDSL hydrolase family protein -
PUP68_RS08365 (PUP68_08365) 1832864..1833331 - 468 WP_053277796.1 GAF domain-containing protein -
PUP68_RS08370 (PUP68_08370) 1833521..1833928 - 408 WP_053277797.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP68_RS08375 (PUP68_08375) 1833961..1834143 - 183 WP_053277798.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP68_RS08380 (PUP68_08380) 1835209..1835925 + 717 WP_053277799.1 molecular chaperone -
PUP68_RS08385 (PUP68_08385) 1836033..1837004 + 972 WP_053277800.1 fimbrial protein -
PUP68_RS08390 (PUP68_08390) 1837173..1837777 - 605 Protein_1655 Arm DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6770.10 Da        Isoelectric Point: 11.6709

>T272795 WP_053277798.1 NZ_CP118139:c1834143-1833961 [Pseudomonas chlororaphis]
VNSRYLIGQIVADGWYLVRVRGSHHPFRPPSKPGLVTVPHPKKDLLRKTAISILKQALLM

Download         Length: 183 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14594.56 Da        Isoelectric Point: 4.3638

>AT272795 WP_053277797.1 NZ_CP118139:c1833928-1833521 [Pseudomonas chlororaphis]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGAAIPSANKVTLHAANPQYAGCTWAL
IDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References