Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 812772..813394 Replicon chromosome
Accession NZ_CP118138
Organism Pseudomonas chlororaphis strain DSM 295782

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PUP77_RS03865 Protein ID WP_053277798.1
Coordinates 812772..812954 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PUP77_RS03870 Protein ID WP_053277797.1
Coordinates 812987..813394 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP77_RS03850 (PUP77_03850) 809138..809742 + 605 Protein_751 Arm DNA-binding domain-containing protein -
PUP77_RS03855 (PUP77_03855) 809911..810882 - 972 WP_053277800.1 fimbrial protein -
PUP77_RS03860 (PUP77_03860) 810990..811706 - 717 WP_053277799.1 molecular chaperone -
PUP77_RS03865 (PUP77_03865) 812772..812954 + 183 WP_053277798.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP77_RS03870 (PUP77_03870) 812987..813394 + 408 WP_053277797.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP77_RS03875 (PUP77_03875) 813584..814051 + 468 WP_053277796.1 GAF domain-containing protein -
PUP77_RS03880 (PUP77_03880) 814181..815095 + 915 WP_274320932.1 SGNH/GDSL hydrolase family protein -
PUP77_RS03885 (PUP77_03885) 815129..816907 - 1779 WP_053277794.1 GGDEF and EAL domain-containing protein -
PUP77_RS03890 (PUP77_03890) 817144..818034 - 891 WP_274320933.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6770.10 Da        Isoelectric Point: 11.6709

>T272788 WP_053277798.1 NZ_CP118138:812772-812954 [Pseudomonas chlororaphis]
VNSRYLIGQIVADGWYLVRVRGSHHPFRPPSKPGLVTVPHPKKDLLRKTAISILKQALLM

Download         Length: 183 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14594.56 Da        Isoelectric Point: 4.3638

>AT272788 WP_053277797.1 NZ_CP118138:812987-813394 [Pseudomonas chlororaphis]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGAAIPSANKVTLHAANPQYAGCTWAL
IDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References