Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2627191..2627776 Replicon chromosome
Accession NZ_CP118137
Organism Pseudomonas chlororaphis strain NCCB 47033

Toxin (Protein)


Gene name PumA Uniprot ID A0A3G7C0N8
Locus tag PUP65_RS11940 Protein ID WP_025804099.1
Coordinates 2627483..2627776 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A3G7CJP2
Locus tag PUP65_RS11935 Protein ID WP_025804100.1
Coordinates 2627191..2627481 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP65_RS11920 (PUP65_11920) 2622516..2624996 + 2481 WP_124325843.1 FtsX-like permease family protein -
PUP65_RS11925 (PUP65_11925) 2624986..2626062 + 1077 WP_124323951.1 lipocalin-like domain-containing protein -
PUP65_RS11930 (PUP65_11930) 2626190..2626777 + 588 WP_063429489.1 hypothetical protein -
PUP65_RS11935 (PUP65_11935) 2627191..2627481 - 291 WP_025804100.1 putative addiction module antidote protein Antitoxin
PUP65_RS11940 (PUP65_11940) 2627483..2627776 - 294 WP_025804099.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PUP65_RS11945 (PUP65_11945) 2628012..2629406 - 1395 WP_124323952.1 VOC family protein -
PUP65_RS11950 (PUP65_11950) 2629669..2630793 + 1125 WP_124323953.1 diguanylate cyclase -
PUP65_RS11955 (PUP65_11955) 2630887..2632131 + 1245 WP_124323954.1 M20/M25/M40 family metallo-hydrolase -
PUP65_RS11960 (PUP65_11960) 2632344..2632742 + 399 WP_016702749.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-96)

Antitoxin

Uncharacterized protein HI1420

(9-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10837.49 Da        Isoelectric Point: 10.7289

>T272786 WP_025804099.1 NZ_CP118137:c2627776-2627483 [Pseudomonas chlororaphis]
MEYEILQTTVFAQWHTRLRDLRARIAIARRIERASAGNLGDVKNLGGGLSEMRVNRGAGYRIYFTVRGNTLIVLLLGGDK
STQPADICQARSLAKEF

Download         Length: 294 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10249.81 Da        Isoelectric Point: 8.0096

>AT272786 WP_025804100.1 NZ_CP118137:c2627481-2627191 [Pseudomonas chlororaphis]
MSDTLVPFDIATLLDSDQAISEYLSQVLADGDTDELIRALGHVARARGMTQIAKATGQGRASLYKAFAPGAKPRFDTVVK
VMRALGLQLCTTVPRG

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G7C0N8

Antitoxin

Source ID Structure
AlphaFold DB A0A3G7CJP2

References