272779

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 6413203..6413792 Replicon chromosome
Accession NZ_CP118136
Organism Pseudomonas chlororaphis strain NCCB 60038

Toxin (Protein)


Gene name PumA Uniprot ID A0A554PHZ9
Locus tag PUP52_RS29110 Protein ID WP_041987451.1
Coordinates 6413493..6413792 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag PUP52_RS29105 Protein ID WP_041987449.1
Coordinates 6413203..6413496 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP52_RS29085 (PUP52_29085) 6408744..6409907 - 1164 WP_041987444.1 acyltransferase -
PUP52_RS29090 (PUP52_29090) 6410102..6411292 - 1191 WP_041987447.1 serine hydrolase domain-containing protein -
PUP52_RS29095 (PUP52_29095) 6411419..6412306 + 888 WP_009051074.1 LysR family transcriptional regulator -
PUP52_RS29100 (PUP52_29100) 6412678..6413070 + 393 WP_009051075.1 hypothetical protein -
PUP52_RS29105 (PUP52_29105) 6413203..6413496 - 294 WP_041987449.1 putative addiction module antidote protein Antitoxin
PUP52_RS29110 (PUP52_29110) 6413493..6413792 - 300 WP_041987451.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PUP52_RS29115 (PUP52_29115) 6413963..6414412 + 450 WP_041987453.1 DUF3828 domain-containing protein -
PUP52_RS29120 (PUP52_29120) 6414437..6415447 - 1011 WP_172833408.1 NAD(P)-dependent alcohol dehydrogenase -
PUP52_RS29125 (PUP52_29125) 6415505..6415804 - 300 WP_009051080.1 helix-turn-helix transcriptional regulator -
PUP52_RS29130 (PUP52_29130) 6415868..6416959 - 1092 WP_041987461.1 copper-containing nitrite reductase -
PUP52_RS29135 (PUP52_29135) 6417185..6417427 + 243 WP_007924102.1 exodeoxyribonuclease VII small subunit -
PUP52_RS29140 (PUP52_29140) 6417424..6418311 + 888 WP_009051083.1 (2E,6E)-farnesyl diphosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11231.97 Da        Isoelectric Point: 10.6086

>T272779 WP_041987451.1 NZ_CP118136:c6413792-6413493 [Pseudomonas chlororaphis]
MIEIKQTATFMEWENRLKDSRARALIAARIFRLANGLAGDVPPVGEGVSELRIHYGPGYRVYFQQLGSQLVILLCGGDKS
RQSRDIELAKQLARRWSRS

Download         Length: 300 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10446.94 Da        Isoelectric Point: 5.6558

>AT272779 WP_041987449.1 NZ_CP118136:c6413496-6413203 [Pseudomonas chlororaphis]
MNEPLFDYDPATSLRDPQAIALFMADAFETGDAGYIAKALGVVARAKGMTELAHETGLSREQLYRSFSDKGNPTLKTLLA
VMRALGLDMTARVHGAS

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A554PHZ9

Antitoxin

Source ID Structure

References