Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3003347..3003951 Replicon chromosome
Accession NZ_CP118136
Organism Pseudomonas chlororaphis strain NCCB 60038

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PUP52_RS13780 Protein ID WP_041988418.1
Coordinates 3003784..3003951 (-) Length 56 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A554PQR3
Locus tag PUP52_RS13775 Protein ID WP_041988420.1
Coordinates 3003347..3003748 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP52_RS13760 (PUP52_13760) 2998585..2999511 + 927 WP_041986432.1 2-dehydropantoate 2-reductase -
PUP52_RS13765 (PUP52_13765) 2999671..3001146 + 1476 WP_041986430.1 aldehyde dehydrogenase family protein -
PUP52_RS13770 (PUP52_13770) 3001273..3002526 + 1254 WP_041986428.1 OprD family porin -
PUP52_RS13775 (PUP52_13775) 3003347..3003748 - 402 WP_041988420.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP52_RS13780 (PUP52_13780) 3003784..3003951 - 168 WP_041988418.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP52_RS13785 (PUP52_13785) 3004331..3004612 - 282 WP_041988415.1 hypothetical protein -
PUP52_RS13790 (PUP52_13790) 3005305..3006630 + 1326 WP_041988412.1 hypothetical protein -
PUP52_RS13795 (PUP52_13795) 3006778..3007158 - 381 WP_124355740.1 hypothetical protein -
PUP52_RS13800 (PUP52_13800) 3008019..3008567 - 549 WP_041988409.1 YniB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(1-54)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 56 a.a.        Molecular weight: 6219.35 Da        Isoelectric Point: 10.6778

>T272777 WP_041988418.1 NZ_CP118136:c3003951-3003784 [Pseudomonas chlororaphis]
MIKELEAAGWVLERVTGSHHLFKHPYRPETVPVPHPKKDLPRGTVRAIQKLAGLI

Download         Length: 168 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14609.56 Da        Isoelectric Point: 4.6017

>AT272777 WP_041988420.1 NZ_CP118136:c3003748-3003347 [Pseudomonas chlororaphis]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAIEIAHVMLEELAREGQTIPLPSPTGTHRANPDFEGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQRIDRFVREHNIKSRSSFLADAAMEKLGR

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A554PQR3

References