Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 546505..547175 Replicon chromosome
Accession NZ_CP118136
Organism Pseudomonas chlororaphis strain NCCB 60038

Toxin (Protein)


Gene name vapC Uniprot ID A0A554PKP7
Locus tag PUP52_RS02445 Protein ID WP_041985377.1
Coordinates 546505..546933 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A3G7DZE9
Locus tag PUP52_RS02450 Protein ID WP_009046453.1
Coordinates 546930..547175 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP52_RS02415 (PUP52_02415) 541727..542236 - 510 WP_009046447.1 DUF1097 domain-containing protein -
PUP52_RS02420 (PUP52_02420) 542270..543010 - 741 WP_016702555.1 SDR family oxidoreductase -
PUP52_RS02425 (PUP52_02425) 543140..544030 + 891 WP_041985374.1 LysR family transcriptional regulator -
PUP52_RS02430 (PUP52_02430) 544155..544337 + 183 WP_009041685.1 type II toxin-antitoxin system HicA family toxin -
PUP52_RS02435 (PUP52_02435) 544367..544768 + 402 WP_009046450.1 type II toxin-antitoxin system HicB family antitoxin -
PUP52_RS02440 (PUP52_02440) 545338..546375 + 1038 WP_016702559.1 L-glyceraldehyde 3-phosphate reductase -
PUP52_RS02445 (PUP52_02445) 546505..546933 - 429 WP_041985377.1 type II toxin-antitoxin system VapC family toxin Toxin
PUP52_RS02450 (PUP52_02450) 546930..547175 - 246 WP_009046453.1 plasmid stabilization protein Antitoxin
PUP52_RS02455 (PUP52_02455) 547315..548154 - 840 WP_009046454.1 taurine dioxygenase -
PUP52_RS02460 (PUP52_02460) 548390..549229 - 840 WP_009046455.1 taurine ABC transporter permease TauC -
PUP52_RS02465 (PUP52_02465) 549226..550020 - 795 WP_028683844.1 taurine ABC transporter ATP-binding subunit -
PUP52_RS02470 (PUP52_02470) 550116..551093 - 978 WP_009046457.1 taurine ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15897.41 Da        Isoelectric Point: 5.4927

>T272776 WP_041985377.1 NZ_CP118136:c546933-546505 [Pseudomonas chlororaphis]
MIVLDTNVLSELMRPQPDTAVLLWIEAQPVEDLYISAMTMAEILHGIARLPHGKRKQTLHASALAMFEEDFIDRIVPFGT
QAALYYTHLVSHRERSGQPINLVDAQIAAICRVHDAAIATRNTKDFTDTGLIVINPWLPLEV

Download         Length: 429 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9103.27 Da        Isoelectric Point: 6.2314

>AT272776 WP_009046453.1 NZ_CP118136:c547175-546930 [Pseudomonas chlororaphis]
MASLTIRNLDDHIKERLRIEAAHNGHSMEEEARLILRRALSRTADSQGLGSRIRARFAETGGVELELPERTEPARLVDLG
E

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A554PKP7

Antitoxin

Source ID Structure
AlphaFold DB A0A3G7DZE9

References