Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 3059018..3059607 Replicon chromosome
Accession NZ_CP118135
Organism Pseudomonas chlororaphis strain NCCB 820532

Toxin (Protein)


Gene name PumA Uniprot ID A0A285IHJ3
Locus tag PUP76_RS14060 Protein ID WP_062824477.1
Coordinates 3059018..3059317 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag PUP76_RS14065 Protein ID WP_007924096.1
Coordinates 3059314..3059607 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP76_RS14030 (PUP76_14030) 3054497..3055384 - 888 WP_053262814.1 (2E,6E)-farnesyl diphosphate synthase -
PUP76_RS14035 (PUP76_14035) 3055381..3055623 - 243 WP_007924102.1 exodeoxyribonuclease VII small subunit -
PUP76_RS14040 (PUP76_14040) 3055849..3056937 + 1089 WP_253366025.1 copper-containing nitrite reductase -
PUP76_RS14045 (PUP76_14045) 3057005..3057304 + 300 WP_007924100.1 helix-turn-helix transcriptional regulator -
PUP76_RS14050 (PUP76_14050) 3057362..3058372 + 1011 WP_274302154.1 NAD(P)-dependent alcohol dehydrogenase -
PUP76_RS14055 (PUP76_14055) 3058397..3058846 - 450 WP_009045812.1 DUF3828 domain-containing protein -
PUP76_RS14060 (PUP76_14060) 3059018..3059317 + 300 WP_062824477.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PUP76_RS14065 (PUP76_14065) 3059314..3059607 + 294 WP_007924096.1 putative addiction module antidote protein Antitoxin
PUP76_RS14070 (PUP76_14070) 3059723..3060115 - 393 WP_274302033.1 hypothetical protein -
PUP76_RS14075 (PUP76_14075) 3060930..3061457 - 528 WP_009045807.1 inorganic diphosphatase -
PUP76_RS14080 (PUP76_14080) 3061722..3062531 - 810 WP_062824480.1 zinc-dependent peptidase -
PUP76_RS14085 (PUP76_14085) 3062537..3063193 - 657 WP_007924093.1 DedA family protein -
PUP76_RS14090 (PUP76_14090) 3063447..3063905 - 459 WP_009045805.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-94)

Antitoxin

Uncharacterized protein HI1420

(6-91)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11261.01 Da        Isoelectric Point: 10.8652

>T272770 WP_062824477.1 NZ_CP118135:3059018-3059317 [Pseudomonas chlororaphis]
MIEIKQTATFMEWENRLKDSRARALIAARIFRLANGLAGDVSPVGEGVSELRIHYGPGYRVYFQQRGLQLVILLCGGDKS
RQGRDIELAKQLARRWSRS

Download         Length: 300 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10430.94 Da        Isoelectric Point: 5.6558

>AT272770 WP_007924096.1 NZ_CP118135:3059314-3059607 [Pseudomonas chlororaphis]
MNEPLFDYDPATALRDPQAIALFMADAFETGDAGYIAKALGVVARAKGMTELAHETGLSREQLYRSFSDKGNPTLKTLLA
VMRALGLDMTARVHGAS

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285IHJ3

Antitoxin

Source ID Structure

References