Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 1980945..1981558 | Replicon | chromosome |
Accession | NZ_CP118135 | ||
Organism | Pseudomonas chlororaphis strain NCCB 820532 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | A0A285EYZ4 |
Locus tag | PUP76_RS09095 | Protein ID | WP_009041685.1 |
Coordinates | 1981376..1981558 (-) | Length | 61 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A2N8BII0 |
Locus tag | PUP76_RS09090 | Protein ID | WP_009041686.1 |
Coordinates | 1980945..1981346 (-) | Length | 134 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PUP76_RS09075 (PUP76_09075) | 1975972..1977297 | - | 1326 | WP_009041689.1 | LLM class flavin-dependent oxidoreductase | - |
PUP76_RS09080 (PUP76_09080) | 1977344..1979602 | - | 2259 | WP_274301721.1 | TonB-dependent receptor | - |
PUP76_RS09085 (PUP76_09085) | 1979810..1980856 | + | 1047 | WP_085533366.1 | LacI family DNA-binding transcriptional regulator | - |
PUP76_RS09090 (PUP76_09090) | 1980945..1981346 | - | 402 | WP_009041686.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
PUP76_RS09095 (PUP76_09095) | 1981376..1981558 | - | 183 | WP_009041685.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
PUP76_RS09100 (PUP76_09100) | 1981683..1982573 | - | 891 | WP_053259258.1 | LysR family transcriptional regulator | - |
PUP76_RS09105 (PUP76_09105) | 1982712..1983452 | + | 741 | WP_009041683.1 | SDR family oxidoreductase | - |
PUP76_RS09110 (PUP76_09110) | 1983486..1983995 | + | 510 | WP_062824006.1 | DUF1097 domain-containing protein | - |
PUP76_RS09115 (PUP76_09115) | 1984025..1984921 | + | 897 | WP_253362331.1 | SDR family oxidoreductase | - |
PUP76_RS09120 (PUP76_09120) | 1984995..1985483 | + | 489 | WP_009041680.1 | DoxX family protein | - |
PUP76_RS09125 (PUP76_09125) | 1985536..1985793 | + | 258 | WP_253362330.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6933.08 Da Isoelectric Point: 10.4588
>T272768 WP_009041685.1 NZ_CP118135:c1981558-1981376 [Pseudomonas chlororaphis]
MRSRELIRMIEEDGWYLIAVKGSHHQYKHLHKPGRVTIPHPDADLPRGTIHSILKQAGLK
MRSRELIRMIEEDGWYLIAVKGSHHQYKHLHKPGRVTIPHPDADLPRGTIHSILKQAGLK
Download Length: 183 bp
Antitoxin
Download Length: 134 a.a. Molecular weight: 14629.48 Da Isoelectric Point: 4.7569
>AT272768 WP_009041686.1 NZ_CP118135:c1981346-1980945 [Pseudomonas chlororaphis]
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAEAFENVKEALSLHYEGLVADGEPLPQVHEVDVHIDNPDYAGGVWGMI
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAEAFENVKEALSLHYEGLVADGEPLPQVHEVDVHIDNPDYAGGVWGMI
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA
Download Length: 402 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A285EYZ4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2N8BII0 |