Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1980945..1981558 Replicon chromosome
Accession NZ_CP118135
Organism Pseudomonas chlororaphis strain NCCB 820532

Toxin (Protein)


Gene name hicA Uniprot ID A0A285EYZ4
Locus tag PUP76_RS09095 Protein ID WP_009041685.1
Coordinates 1981376..1981558 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2N8BII0
Locus tag PUP76_RS09090 Protein ID WP_009041686.1
Coordinates 1980945..1981346 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP76_RS09075 (PUP76_09075) 1975972..1977297 - 1326 WP_009041689.1 LLM class flavin-dependent oxidoreductase -
PUP76_RS09080 (PUP76_09080) 1977344..1979602 - 2259 WP_274301721.1 TonB-dependent receptor -
PUP76_RS09085 (PUP76_09085) 1979810..1980856 + 1047 WP_085533366.1 LacI family DNA-binding transcriptional regulator -
PUP76_RS09090 (PUP76_09090) 1980945..1981346 - 402 WP_009041686.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP76_RS09095 (PUP76_09095) 1981376..1981558 - 183 WP_009041685.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP76_RS09100 (PUP76_09100) 1981683..1982573 - 891 WP_053259258.1 LysR family transcriptional regulator -
PUP76_RS09105 (PUP76_09105) 1982712..1983452 + 741 WP_009041683.1 SDR family oxidoreductase -
PUP76_RS09110 (PUP76_09110) 1983486..1983995 + 510 WP_062824006.1 DUF1097 domain-containing protein -
PUP76_RS09115 (PUP76_09115) 1984025..1984921 + 897 WP_253362331.1 SDR family oxidoreductase -
PUP76_RS09120 (PUP76_09120) 1984995..1985483 + 489 WP_009041680.1 DoxX family protein -
PUP76_RS09125 (PUP76_09125) 1985536..1985793 + 258 WP_253362330.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6933.08 Da        Isoelectric Point: 10.4588

>T272768 WP_009041685.1 NZ_CP118135:c1981558-1981376 [Pseudomonas chlororaphis]
MRSRELIRMIEEDGWYLIAVKGSHHQYKHLHKPGRVTIPHPDADLPRGTIHSILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14629.48 Da        Isoelectric Point: 4.7569

>AT272768 WP_009041686.1 NZ_CP118135:c1981346-1980945 [Pseudomonas chlororaphis]
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAEAFENVKEALSLHYEGLVADGEPLPQVHEVDVHIDNPDYAGGVWGMI
EFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285EYZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A2N8BII0

References