Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 735246..735868 Replicon chromosome
Accession NZ_CP118135
Organism Pseudomonas chlororaphis strain NCCB 820532

Toxin (Protein)


Gene name hicA Uniprot ID A0A285HEJ8
Locus tag PUP76_RS03430 Protein ID WP_053259927.1
Coordinates 735246..735428 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A285HET1
Locus tag PUP76_RS03435 Protein ID WP_009042564.1
Coordinates 735461..735868 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP76_RS03405 (PUP76_03405) 730275..731159 + 885 WP_009042569.1 alpha/beta hydrolase -
PUP76_RS03415 (PUP76_03415) 731672..732197 + 526 Protein_664 integrase -
PUP76_RS03420 (PUP76_03420) 732366..733337 - 972 WP_274301356.1 fimbrial protein -
PUP76_RS03425 (PUP76_03425) 733459..734181 - 723 WP_253362990.1 molecular chaperone -
PUP76_RS03430 (PUP76_03430) 735246..735428 + 183 WP_053259927.1 type II toxin-antitoxin system HicA family toxin Toxin
PUP76_RS03435 (PUP76_03435) 735461..735868 + 408 WP_009042564.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP76_RS03440 (PUP76_03440) 735915..736118 + 204 WP_239691046.1 hypothetical protein -
PUP76_RS03445 (PUP76_03445) 736248..737162 + 915 WP_274301357.1 SGNH/GDSL hydrolase family protein -
PUP76_RS03450 (PUP76_03450) 737196..738974 - 1779 WP_274301358.1 GGDEF and EAL domain-containing protein -
PUP76_RS03455 (PUP76_03455) 739213..740103 - 891 WP_274302138.1 LysR family transcriptional regulator -
PUP76_RS03460 (PUP76_03460) 740206..740868 + 663 WP_274301359.1 NAD(P)-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6873.18 Da        Isoelectric Point: 11.1084

>T272764 WP_053259927.1 NZ_CP118135:735246-735428 [Pseudomonas chlororaphis]
VDSRYLIGQIVADGWYLVRVRGSHHHFKHPHKPGLVTVPHPKKDLLRKTAISILKQALLM

Download         Length: 183 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14698.72 Da        Isoelectric Point: 4.5911

>AT272764 WP_009042564.1 NZ_CP118135:735461-735868 [Pseudomonas chlororaphis]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGAPIPHANKVTLHAANPRYAGCTWAL
IDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285HEJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A285HET1

References