Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 2686405..2687018 Replicon chromosome
Accession NZ_CP118134
Organism Pseudomonas synxantha strain ATCC 17413

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PUP72_RS12120 Protein ID WP_046072224.1
Coordinates 2686767..2687018 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PUP72_RS12115 Protein ID WP_274358364.1
Coordinates 2686405..2686770 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUP72_RS12090 (PUP72_12090) 2681618..2682427 + 810 WP_056846805.1 ammonia-dependent NAD(+) synthetase -
PUP72_RS12095 (PUP72_12095) 2682578..2683150 + 573 WP_274358360.1 DUF2239 family protein -
PUP72_RS12100 (PUP72_12100) 2683173..2684528 + 1356 WP_274358361.1 MATE family efflux transporter -
PUP72_RS12105 (PUP72_12105) 2684512..2685099 - 588 WP_274358362.1 TetR/AcrR family transcriptional regulator -
PUP72_RS12110 (PUP72_12110) 2685232..2686404 + 1173 WP_274358363.1 MFS transporter -
PUP72_RS12115 (PUP72_12115) 2686405..2686770 - 366 WP_274358364.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PUP72_RS12120 (PUP72_12120) 2686767..2687018 - 252 WP_046072224.1 type II toxin-antitoxin system HicA family toxin Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9546.13 Da        Isoelectric Point: 10.0941

>T272761 WP_046072224.1 NZ_CP118134:c2687018-2686767 [Pseudomonas synxantha]
VSKNEKLLAKLLNEHMAFTWPELVTLLRRLGYTQIEGAGSRVKFDIGDPSAMITLHRPHPGNELKHYIRRQIIEQLKSGE
LIQ

Download         Length: 252 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13195.06 Da        Isoelectric Point: 6.6274

>AT272761 WP_274358364.1 NZ_CP118134:c2686770-2686405 [Pseudomonas synxantha]
VNNQLKHNGYIGSIEASLEDNCLFGKVLFIKALVSFEGKTVAELEAAFREAVDDYLATCQALGQTPEKPCKGSFNVRVGH
DLHLAAALAATRKKVTLNDLTRQALSEFLQHHYPEPCPAIG

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References