Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-HTH_XRE
Location 2168873..2170116 Replicon chromosome
Accession NZ_CP118097
Organism Streptococcus dysgalactiae subsp. equisimilis strain MGCS35922

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag MGCS35922_RS10660 Protein ID WP_084916287.1
Coordinates 2168873..2169640 (-) Length 256 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag MGCS35922_RS10665 Protein ID WP_084916288.1
Coordinates 2169640..2170116 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MGCS35922_RS10635 (MGCS35922_04332) 2164143..2165243 + 1101 WP_000168218.1 type IV secretion system DNA-binding domain-containing protein -
MGCS35922_RS10640 (MGCS35922_04334) 2165240..2165845 + 606 WP_275926351.1 hypothetical protein -
MGCS35922_RS10645 (MGCS35922_04336) 2166051..2166656 + 606 WP_001040935.1 replication protein -
MGCS35922_RS10650 (MGCS35922_04338) 2166649..2166897 + 249 WP_001058391.1 MerR family transcriptional regulator -
MGCS35922_RS10655 (MGCS35922_04340) 2166987..2168252 + 1266 WP_275926352.1 site-specific integrase -
MGCS35922_RS10660 (MGCS35922_04342) 2168873..2169640 - 768 WP_084916287.1 type II toxin-antitoxin system toxin PezT Toxin
MGCS35922_RS10665 (MGCS35922_04344) 2169640..2170116 - 477 WP_084916288.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
MGCS35922_RS10670 (MGCS35922_04346) 2170271..2170438 - 168 Protein_2047 peptidylprolyl isomerase -
MGCS35922_RS10675 (MGCS35922_04348) 2170701..2171867 - 1167 WP_227986119.1 MFS transporter -
MGCS35922_RS10680 (MGCS35922_04350) 2171851..2172627 - 777 WP_061600517.1 arginase family protein -
MGCS35922_RS10685 (MGCS35922_04352) 2172624..2173802 - 1179 WP_159333946.1 radical SAM protein -
MGCS35922_RS10690 (MGCS35922_04354) 2173893..2174756 - 864 Protein_2051 IS982 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2146658..2182633 35975
- flank IS/Tn - - 2174142..2174756 614


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 29124.02 Da        Isoelectric Point: 6.3943

>T272756 WP_084916287.1 NZ_CP118097:c2169640-2168873 [Streptococcus dysgalactiae subsp. equisimilis]
MKLEEFSQDNFEQASKRLVRSLTRGKTTSSQPKAILLGGQSGAGKTTIHRIKQREFQGNIIIIDGDSYRSFHPNYLGLQE
RYGKDSVDYTKVFAGQMVEYLVDELSKKGYHLLIEGTLRTTEVPKKTAQLLTTKGYQVSLAVIATKPELSYLSTLIRYEE
LHAIDPSQARATPKEHHDGIVEHLVDNLRELENDKIFNQIQIYQRDQSCIYDSQVDQISAAEVLQECLFGKWSKVEEEML
KLGQERLKELGEIDK

Download         Length: 768 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18120.68 Da        Isoelectric Point: 4.6272

>AT272756 WP_084916288.1 NZ_CP118097:c2170116-2169640 [Streptococcus dysgalactiae subsp. equisimilis]
MIGENIKTLRKAHNLTQPEFAKIVGISRNSLSRYENGTSRVSTELIDRICKKFNVSYIDIVGEEKMLTPVEDYQLTLKIE
VIKERGANILAQLYRFQDEQGIAFDDTSNPWVLMSDDLSDLINTKIYLVATFEDIERFNGYLDGIERMLEQATHLVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References