Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1392362..1392928 Replicon chromosome
Accession NZ_CP118083
Organism Bifidobacterium breve strain VSI11

Toxin (Protein)


Gene name relE Uniprot ID A0A0L7AXF3
Locus tag PUW55_RS06610 Protein ID WP_025262990.1
Coordinates 1392635..1392928 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag PUW55_RS06605 Protein ID WP_025221722.1
Coordinates 1392362..1392631 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUW55_RS06580 (PUW55_06580) 1388111..1388797 - 687 WP_013140734.1 response regulator transcription factor -
PUW55_RS06585 (PUW55_06585) 1388929..1389447 + 519 WP_223261719.1 hypothetical protein -
PUW55_RS06590 (PUW55_06590) 1389444..1390334 + 891 WP_003831809.1 hypothetical protein -
PUW55_RS06595 (PUW55_06595) 1390331..1391011 + 681 WP_003829413.1 ABC transporter ATP-binding protein -
PUW55_RS06600 (PUW55_06600) 1391017..1392177 + 1161 WP_032742829.1 ABC transporter permease -
PUW55_RS06605 (PUW55_06605) 1392362..1392631 + 270 WP_025221722.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PUW55_RS06610 (PUW55_06610) 1392635..1392928 + 294 WP_025262990.1 type II toxin-antitoxin system YafQ family toxin Toxin
PUW55_RS06615 (PUW55_06615) 1393272..1393400 + 129 WP_003829419.1 hypothetical protein -
PUW55_RS06620 (PUW55_06620) 1393597..1394148 + 552 WP_012577735.1 RNA polymerase sigma factor -
PUW55_RS06625 (PUW55_06625) 1394182..1395009 + 828 WP_071474967.1 hypothetical protein -
PUW55_RS06630 (PUW55_06630) 1395141..1395767 + 627 WP_012577737.1 hypothetical protein -
PUW55_RS06635 (PUW55_06635) 1395764..1396546 + 783 WP_077386957.1 murein hydrolase transporter LrgB -
PUW55_RS06640 (PUW55_06640) 1396599..1397474 + 876 WP_077386959.1 ABC transporter ATP-binding protein -
PUW55_RS06645 (PUW55_06645) 1397529..1397927 + 399 WP_015438839.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1380605..1405141 24536


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-88)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11190.93 Da        Isoelectric Point: 9.7881

>T272748 WP_025262990.1 NZ_CP118083:1392635-1392928 [Bifidobacterium breve]
MLKPDYTAAFQRDIKKLKRKHTDLRPLKEVIRLVLEDTADSKEALRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGK

Download         Length: 294 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9859.22 Da        Isoelectric Point: 6.3186

>AT272748 WP_025221722.1 NZ_CP118083:1392362-1392631 [Bifidobacterium breve]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMKALDEAKNRLADGKPRFNSA
DEMFDSLGI

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L7AXF3

Antitoxin

Source ID Structure

References