Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-couple_hipB |
| Location | 684593..685836 | Replicon | chromosome |
| Accession | NZ_CP118080 | ||
| Organism | Streptococcus agalactiae strain VSI14 | ||
Toxin (Protein)
| Gene name | sezT | Uniprot ID | G7SEB4 |
| Locus tag | PUW74_RS03730 | Protein ID | WP_001235242.1 |
| Coordinates | 685069..685836 (+) | Length | 256 a.a. |
Antitoxin (Protein)
| Gene name | sezA | Uniprot ID | - |
| Locus tag | PUW74_RS03725 | Protein ID | WP_000578719.1 |
| Coordinates | 684593..685069 (+) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PUW74_RS03700 (PUW74_03700) | 680686..682377 | + | 1692 | WP_050547274.1 | recombinase family protein | - |
| PUW74_RS03705 (PUW74_03705) | 682441..683541 | + | 1101 | WP_000196859.1 | toprim domain-containing protein | - |
| PUW74_RS03710 (PUW74_03710) | 683569..683796 | + | 228 | WP_000110922.1 | DUF5965 family protein | - |
| PUW74_RS03715 (PUW74_03715) | 683793..684182 | + | 390 | WP_000048066.1 | DUF5945 family protein | - |
| PUW74_RS03720 (PUW74_03720) | 684233..684523 | + | 291 | WP_000667951.1 | hypothetical protein | - |
| PUW74_RS03725 (PUW74_03725) | 684593..685069 | + | 477 | WP_000578719.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| PUW74_RS03730 (PUW74_03730) | 685069..685836 | + | 768 | WP_001235242.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| PUW74_RS03735 (PUW74_03735) | 685873..688380 | + | 2508 | WP_001213955.1 | AAA family ATPase | - |
| PUW74_RS03740 (PUW74_03740) | 688718..689080 | + | 363 | WP_000140674.1 | SAG1252 family conjugative relaxosome accessory protein | - |
| PUW74_RS03745 (PUW74_03745) | 689083..689448 | + | 366 | WP_274982470.1 | MobC family plasmid mobilization relaxosome protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | tet(O) / ant(6)-Ia / aph(3')-III / erm(B) | gbs0628 / gbs0630 | 605961..712193 | 106232 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 256 a.a. Molecular weight: 28985.80 Da Isoelectric Point: 5.1126
>T272745 WP_001235242.1 NZ_CP118080:685069-685836 [Streptococcus agalactiae]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK
Download Length: 768 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 18266.77 Da Isoelectric Point: 4.6424
>AT272745 WP_000578719.1 NZ_CP118080:684593-685069 [Streptococcus agalactiae]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|