Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 249727..250339 Replicon chromosome
Accession NZ_CP118080
Organism Streptococcus agalactiae strain VSI14

Toxin (Protein)


Gene name parE Uniprot ID A0A8G2N8L3
Locus tag PUW74_RS01450 Protein ID WP_000384860.1
Coordinates 249727..250062 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E7D2
Locus tag PUW74_RS01455 Protein ID WP_000259017.1
Coordinates 250052..250339 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUW74_RS01425 (PUW74_01425) 244925..245566 + 642 WP_000591144.1 hypothetical protein -
PUW74_RS01430 (PUW74_01430) 245866..246741 + 876 WP_000421240.1 hypothetical protein -
PUW74_RS01435 (PUW74_01435) 246777..247211 + 435 WP_001220479.1 hypothetical protein -
PUW74_RS01440 (PUW74_01440) 247528..248784 + 1257 WP_000122836.1 MobV family relaxase -
PUW74_RS01445 (PUW74_01445) 248952..249422 + 471 WP_000130119.1 hypothetical protein -
PUW74_RS01450 (PUW74_01450) 249727..250062 - 336 WP_000384860.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PUW74_RS01455 (PUW74_01455) 250052..250339 - 288 WP_000259017.1 hypothetical protein Antitoxin
PUW74_RS01460 (PUW74_01460) 250846..251136 + 291 WP_000078283.1 WXG100 family type VII secretion target -
PUW74_RS01465 (PUW74_01465) 251238..251644 + 407 Protein_233 hypothetical protein -
PUW74_RS01470 (PUW74_01470) 251644..252204 + 561 WP_001865562.1 hypothetical protein -
PUW74_RS01475 (PUW74_01475) 252177..252857 + 681 WP_001865565.1 hypothetical protein -
PUW74_RS01480 (PUW74_01480) 252842..253228 + 387 WP_000259069.1 hypothetical protein -
PUW74_RS01485 (PUW74_01485) 253262..253543 + 282 WP_000052406.1 hypothetical protein -
PUW74_RS01490 (PUW74_01490) 254375..255235 + 861 WP_000477654.1 Rgg/GadR/MutR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 241758..250613 8855


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13227.87 Da        Isoelectric Point: 4.5348

>T272742 WP_000384860.1 NZ_CP118080:c250062-249727 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENSVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10906.50 Da        Isoelectric Point: 4.7271

>AT272742 WP_000259017.1 NZ_CP118080:c250339-250052 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A076Z4V6

References