272741

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-couple_hipB
Location 684593..685836 Replicon chromosome
Accession NZ_CP118079
Organism Streptococcus agalactiae strain VSI15

Toxin (Protein)


Gene name sezT Uniprot ID G7SEB4
Locus tag PUW77_RS03730 Protein ID WP_001235242.1
Coordinates 685069..685836 (+) Length 256 a.a.

Antitoxin (Protein)


Gene name sezA Uniprot ID -
Locus tag PUW77_RS03725 Protein ID WP_000578719.1
Coordinates 684593..685069 (+) Length 159 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUW77_RS03700 (PUW77_03700) 680686..682377 + 1692 WP_050547274.1 recombinase family protein -
PUW77_RS03705 (PUW77_03705) 682441..683541 + 1101 WP_000196859.1 toprim domain-containing protein -
PUW77_RS03710 (PUW77_03710) 683569..683796 + 228 WP_000110922.1 DUF5965 family protein -
PUW77_RS03715 (PUW77_03715) 683793..684182 + 390 WP_000048066.1 DUF5945 family protein -
PUW77_RS03720 (PUW77_03720) 684233..684523 + 291 WP_000667951.1 hypothetical protein -
PUW77_RS03725 (PUW77_03725) 684593..685069 + 477 WP_000578719.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
PUW77_RS03730 (PUW77_03730) 685069..685836 + 768 WP_001235242.1 type II toxin-antitoxin system toxin PezT Toxin
PUW77_RS03735 (PUW77_03735) 685873..688380 + 2508 WP_001213955.1 AAA family ATPase -
PUW77_RS03740 (PUW77_03740) 688718..689080 + 363 WP_000140674.1 SAG1252 family conjugative relaxosome accessory protein -
PUW77_RS03745 (PUW77_03745) 689083..689448 + 366 WP_274982470.1 MobC family plasmid mobilization relaxosome protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(O) / ant(6)-Ia / aph(3')-III / erm(B) gbs0628 / gbs0630 605961..712193 106232


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(28-214)

Antitoxin

(3-60)


Sequences


Toxin        


Download         Length: 256 a.a.        Molecular weight: 28985.80 Da        Isoelectric Point: 5.1126

>T272741 WP_001235242.1 NZ_CP118079:685069-685836 [Streptococcus agalactiae]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK

Download         Length: 768 bp


Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18266.77 Da        Isoelectric Point: 4.6424

>AT272741 WP_000578719.1 NZ_CP118079:684593-685069 [Streptococcus agalactiae]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA

Download         Length: 477 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G7SEB4


Antitoxin

Source ID Structure

References