Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 981527..982298 Replicon chromosome
Accession NZ_CP118060
Organism Staphylococcus haemolyticus strain VSI35

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag PUW68_RS05010 Protein ID WP_141738627.1
Coordinates 982149..982298 (+) Length 50 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag PUW68_RS05005 Protein ID WP_070581253.1
Coordinates 981527..982126 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUW68_RS04985 (PUW68_04985) 977410..978864 + 1455 Protein_947 ABC transporter substrate-binding protein/permease -
PUW68_RS04990 (PUW68_04990) 978857..979579 + 723 WP_070844347.1 amino acid ABC transporter ATP-binding protein -
PUW68_RS04995 (PUW68_04995) 979757..980884 + 1128 WP_053025430.1 tRNA epoxyqueuosine(34) reductase QueG -
PUW68_RS05000 (PUW68_05000) 980885..981355 + 471 WP_053025428.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
PUW68_RS05005 (PUW68_05005) 981527..982126 + 600 WP_070581253.1 glucosamine-6-phosphate isomerase Antitoxin
PUW68_RS05010 (PUW68_05010) 982149..982298 + 150 WP_141738627.1 SAS053 family protein Toxin
PUW68_RS05015 (PUW68_05015) 982509..982904 + 396 WP_053025423.1 hypothetical protein -
PUW68_RS05020 (PUW68_05020) 983110..984495 + 1386 WP_053025421.1 class II fumarate hydratase -
PUW68_RS05025 (PUW68_05025) 984561..985385 - 825 WP_053025419.1 RluA family pseudouridine synthase -
PUW68_RS05030 (PUW68_05030) 985573..986682 + 1110 WP_070581254.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside SCCmec - - 900998..1184062 283064


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5824.20 Da        Isoelectric Point: 3.9484

>T272733 WP_141738627.1 NZ_CP118060:982149-982298 [Staphylococcus haemolyticus]
MTKNKDSELNYHEEENAMVQDLDDLKTLGKEMEQISEENDEDRLNQSHE

Download         Length: 150 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22286.14 Da        Isoelectric Point: 4.7588

>AT272733 WP_070581253.1 NZ_CP118060:981527-982126 [Staphylococcus haemolyticus]
MAMNFKVFNDVEHVAEYTADIIRKQFNNNPTTIAGIHLTKDAAPVIDELKKDVDHNAVDFSQVNILDYDDNRSYYEALGV
PTSQIYPINLDDDAESLIDDKIKTKENKGKLILQVTSIDESGSLNVNVRQGLLKAREVVLVVTGANKREVVKKLYEENGK
SSFEPADLKAHRMVTVVLDRAAAEGLPEDVKEYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References