Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 846371..846903 Replicon chromosome
Accession NZ_CP118060
Organism Staphylococcus haemolyticus strain VSI35

Toxin (Protein)


Gene name mazF Uniprot ID Q4L7V3
Locus tag PUW68_RS04215 Protein ID WP_011275272.1
Coordinates 846538..846903 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag PUW68_RS04210 Protein ID WP_049426542.1
Coordinates 846371..846541 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUW68_RS04185 (PUW68_04185) 842157..842636 + 480 WP_070580730.1 PH domain-containing protein -
PUW68_RS04190 (PUW68_04190) 842629..844152 + 1524 WP_242305279.1 PH domain-containing protein -
PUW68_RS04195 (PUW68_04195) 844145..844672 + 528 WP_070580727.1 PH domain-containing protein -
PUW68_RS04200 (PUW68_04200) 844682..845041 + 360 WP_070580725.1 holo-ACP synthase -
PUW68_RS04205 (PUW68_04205) 845137..846285 + 1149 WP_049426543.1 alanine racemase -
PUW68_RS04210 (PUW68_04210) 846371..846541 + 171 WP_049426542.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PUW68_RS04215 (PUW68_04215) 846538..846903 + 366 WP_011275272.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PUW68_RS04220 (PUW68_04220) 847211..848212 + 1002 WP_053020219.1 PP2C family protein-serine/threonine phosphatase -
PUW68_RS04225 (PUW68_04225) 848311..848637 + 327 WP_049426540.1 anti-sigma factor antagonist -
PUW68_RS04230 (PUW68_04230) 848666..849118 + 453 WP_049426550.1 anti-sigma B factor RsbW -
PUW68_RS04235 (PUW68_04235) 849093..849863 + 771 WP_011275276.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13672.75 Da        Isoelectric Point: 8.4121

>T272732 WP_011275272.1 NZ_CP118060:846538-846903 [Staphylococcus haemolyticus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSDEKMQEVDEALDISLGLHDEVKTQNT

Download         Length: 366 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.08 Da        Isoelectric Point: 4.0325

>AT272732 WP_049426542.1 NZ_CP118060:846371-846541 [Staphylococcus haemolyticus]
MLTFNQNRSHSLEQSLKEGYSQMAELNLSLATEAFPLECEACDCNETYIISNYKSE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KA75

Antitoxin

Source ID Structure

References